2009 Fiscal Year Final Research Report
The institution of reference nutrient intake on phosphate, aimed reduction for cardiovascular disease risk
| Project/Area Number |
20800038
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHUTO Emi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (10512121)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 動脈硬化 |
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| Research Abstract |
Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease. To determine whether postprandial hyperphosphatemia may promote endothelial dysfunction, we investigated the acute effect of phosphorus loading on endothelial function in 11 healthy men. The high dietary phosphorus load increased serum phosphorus and significantly decreased flow-mediated dilation. Flow-mediated dilation correlated inversely with serum phosphorus. These findings suggest that endothelial dysfunction mediated by acute postprandial hyperphosphatemia may contribute to the relationship between serum phosphorus level and the risk for cardiovascular morbidity and mortality.
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[Journal Article] Dietary phosphorus acutely impairs endothelial function.2009
Author(s)
Emi Shuto, Yutaka Taketani, Rieko Tanaka, agakatsu Harada, Masashi lsshiki, Minako Sato, Kunitaka Nashiki, Kikuko Amo, Hironori Yamamoto, Yukihito Higashi, Yutaka Nakaya, Eiji Takeda
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Journal Title
Journal of the American Society of Nephrology Vol.20
Pages: 1504-1512
Peer Reviewed
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