2022 Fiscal Year Final Research Report
Mechanism of cardiomyocyte cell cycle regulation through stress response pathways
| Project/Area Number |
20H03680
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kimura Wataru 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (60452182)
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| Co-Investigator(Kenkyū-buntansha) |
升本 英利 国立研究開発法人理化学研究所, 生命機能科学研究センター, 上級研究員 (70645754)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 心筋梗塞 / 心筋再生 / 心筋細胞 / AMPK |
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| Outline of Final Research Achievements |
Although adult mammals do not possess the capacity to regenerate the heart following injuries such as myocardial infarction, fetal and early neonatal mammals do possess such capacity. In previous studies, we have shown that oxidative stress response pathways play critical roles in regulating regenerative abilities in the heart in mammals. In the current study, we sought to identify pathways that control such stress response pathways in the neonatal heart. As a result, we identified AMPK signaling as a critical regulator of the cardiomyocyte cell cycle and capacity for cardiac regeneration in the postnatal mammalian heart.
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| Free Research Field |
再生生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は，哺乳類の心筋再生を制御する分子機構の一端を明らかにするものである．これらの成果をもとに，さらに研究を進めていく．具体的には，新生仔において，あるいはAMPKシグナルの上流，下流においてどのような機構がはたらき心筋再生能が喪失するかを解明し，さらにAMPK自体や上流，下流の阻害によって成体において心筋再生が誘導されるかを検討する．これらの研究により，新たな心筋再生法の開発につながる基盤的知見が得られるものと期待される．
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