Establishment of a novel therapy for glioblastoma with Alternative Magnetic Fields

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09396
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Yokohama City University
• Principal Investigator: YAMAMOTO Tetsuya 横浜市立大学, 医学研究科, 教授 (30375505)
• Co-Investigator(Kenkyū-buntansha): 末永 潤 横浜市立大学, 医学部, 講師 (30610365) ; 秋本 大輔 横浜市立大学, 附属市民総合医療センター, 助教 (90846718)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 悪性神経膠芽腫 / 交流磁場 / 物理的刺激

Outline of Final Research Achievements

We successfully proceeded with developing a new treatment for malignant glioblastoma, which is highly resistant to radiotherapy and chemotherapy, using Alternative magnetic fields, and to advance our research to the stage of creating detailed specifications for the equipment for clinical use. We confirmed an inhibitory effect on stem cell transformation, which may be effective against a very small number of cancer stem cells that cause recurrence and are highly resistant to therapy, and metabolic changes in metabolome analysis, which may be an anti-Warburg effect in VIVO. There are still issues to be solved for clinical application, such as instability of the Alternative magnetic field stimulation and countermeasures against heat generation from the device.

Free Research Field

脳腫瘍

Academic Significance and Societal Importance of the Research Achievements

近年、放射線治療や化学療法抵抗性の強い神経膠芽腫に対して、物理学的刺激を用いた治療法が臨床応用されてきている。その代表が温熱治療や交流電場を用いたNOVOTTFがある。いずれも発熱による火傷や、全剃毛や長時間の装置の装着を必要とするなどデメリットもある治療である。我々の開発している治療器具は30分から１時間程度の照射を１週間に数回繰り返すことで治療効果を得られる低侵襲な装置となる可能性がある。