Effects of chronic exercise on interactions between muscle and bone

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09514
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Kindai University
• Principal Investigator: Kaji Hiroshi 近畿大学, 医学部, 教授 (90346255)
• Co-Investigator(Kenkyū-buntansha): 河尾 直之 近畿大学, 医学部, 講師 (70388510)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 筋骨連関 / 慢性運動 / マイオカイン

Outline of Final Research Achievements

Exercise therapy is beneficial for the prevention and treatment of osteoporosis and sarcopenia. Skeletal muscle affects other tissues via myokines, the release of which is regulated by acute exercise. However, the effects of chronic exercise on interactions between muscle and bone have not been fully elucidated. The present study was performed to investigate the effects of chronic exercise on skeletal muscle, bone, and interactions between muscle and bone in mice. Moreover, we aimed to identify a novel myokine whose expression is increased by chronic exercise in the skeletal muscle and affects bone metabolism. In the present study, we found that chronic exercise increased expression of irisin and peripheral myelin protein 22 (PMP22) in the skeletal muscle of mice. Moreover, irisin and PMP22 might be involved in the beneficial effects of chronic exercise on bone in mice.

Free Research Field

骨代謝学

Academic Significance and Societal Importance of the Research Achievements

高齢化社会の進展とともに健康寿命の延伸が喫緊の課題となる中で、骨粗鬆症とサルコペニアの予防・治療が重要となってきた。その中で、骨格筋と骨の相互関連（筋・骨連関）が注目されいる。本研究課題の成果から、長期的な運動により調節される骨格筋由来の新しいマイオカインとして見出したアイリシンとPMP22が、未だ臨床の場に登場していない運動療法のバイオマーカーとなる可能性が考えられる。さらに、アイリシンとPMP22の筋と骨における役割の解明が進むことにより、サルコペニアと骨粗鬆症を同時に対象とする治療薬や診断法の開発に繋がる可能性も期待できる。