Mechanisms of blood glucose re-distribution to enhance blood glucose supply to active muscle - focusing on glucose uptake in inactive muscle

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K11326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: The University of Tokushima
• Principal Investigator: RA Song-Gyu 徳島大学, 教養教育院, 准教授 (60741999)
• Co-Investigator(Kenkyū-buntansha): 檜垣 靖樹 福岡大学, スポーツ科学部, 教授 (10228702) ; 川中 健太郎 福岡大学, スポーツ科学部, 教授 (80339960)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 血糖 / 糖取り込み / 非活動筋 / TXNIP / AMPK

Outline of Final Research Achievements

We have previously shown that thioredoxin-interacting protein (TXNIP), which inhibits skeletal muscle glucose uptake, is decreased in exercised muscle during exercise. However, changes in TXNIP in non-exercised muscle have not been clarified.
In the present study, we examined changes in skeletal muscle glucose uptake and TXNIP in both exercised and non-exercised muscle during exercise. The results of this study revealed that the expression of TXNIP increased during exercise in non-exercised muscle, in contrast to exercised muscle. The results also indicated that the activity level of AMPK in the muscle may be involved in this change in TXNIP. However, glucose uptake in non-exercised muscle did not decrease with increasing TXINP.

Free Research Field

運動栄養学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、運動時に糖の取り込みが高まる活動筋とは対照的に、非活動筋においては糖取り込みを負に制御するTXNIPの発現量が高まることが示された。すなわち、運動中には非活動筋においてTXNIP発現量が高まり糖取り込みが低下することで、残った血糖を活動筋へ分配する血糖維持機構が存在する可能性がある。非活動筋に着目した研究を進めることで、持久性アスリートの運動パフォーマンス向上に資する成果が期待される。