2022 Fiscal Year Final Research Report
Development of a pulatile VAD having a valve mimicking aortic valve
| Project/Area Number |
20K12611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Vibrating Flow Pump / LVAD / Check Valve / Fluid Circuit / Pump Characteristics |
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| Outline of Final Research Achievements |
We focus on vibrating flow pump (VFP) to develop a LVAD that generates pulsatile flow. Conventional VFP has used Jelly-fish valve as the check valve. It has been pointed out that there is a risk of hemolysis by shear of the blood in passing through the valve. Therefore, we proposed using a check valve which mimics structure of the aortic valve. In this study, we developed a pump system of the VFP and observed the pump characteristics using the proposed valve. It was shown that the pump discharged more flow and generated higher head using the proposed valve compared to the Jelly-fish valve. Slope of the P-Q curve, however, changed greatly depending on the driving frequency of the pump.
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| Free Research Field |
Biofluid Mechanics
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| Academic Significance and Societal Importance of the Research Achievements |
現在使用される左心補助人工心臓(LVAD)は，体内に植え込むために小型化が容易な定常流型がほとんどであるが，血流の拍動が無いと末梢での血行障害等が危惧される．そこで本研究では，拍動流を生成するLVADの開発を目標として，構造が簡単で小型化が可能な振動型ポンプに着目し，従来の振動型ポンプの問題点である逆止弁での溶血の危険性を低減するために，大動脈弁を模擬した構造の弁を用いることを提案した．本研究で得られた知見は，この新たなLVAD開発の最も基礎となるものであり，今後の改良の重要な指針となる．
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