Proofreading mechanisms in mitochondrial protein transport.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K15794
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 44010:Cell biology-related
• Research Institution: Kyushu University
• Principal Investigator: Matsumoto Shunsuke 九州大学, 農学研究院, 助教 (70704295)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Msp1 / ミトコンドリア / タンパク質輸送 / 配送のやり直し

Outline of Final Research Achievements

We hypothesized the AAA-ATPase Msp1 on the mitochondrial outer membrane (OM) extracts precursor proteins that fail to translocate into the mitochondria from the OM, giving them a chance to re-import into the mitochondria, and tested this hypothesis using budding yeast. We also showed that mislocalized tail-anchored (TA) proteins extracted into cytosol by Msp1 are re-located to the endoplasmic reticulum membrane via the guided-entry of TA proteins pathway.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的な独創性・創造性は、生命の基本過程であるタンパク質輸送において、遺伝子の複製や翻訳などの「校正メカニズム」の存在を証明し、タンパク質輸送の校正という新しい概念を確立することにある。また、タンパク質輸送の阻害によって引き起こされる病態の解明や、治療法の開発につながることが期待される。