2021 Fiscal Year Final Research Report
Elucidation of the effect of CAPE on inflammation control and VEGF production in pulpitis lesions
| Project/Area Number |
20K23084
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2020-09-11 – 2022-03-31
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| Keywords | 歯髄炎 / CAPE / VEGF / 抗炎症 / 歯髄保護療法 |
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| Outline of Final Research Achievements |
In this study, I investigated the effects of CAPE, a physiologically active substance of propolis, on inflammatory cytokines and VEGF production in human dental pulp cells to develop a novel treatment by a more ideal dental pulp protective agent. I found that CAPE could inhibit CXCL10 production in Pam3CSK4- and TNF-α-stimulated human dental pulp cells. Moreover, CAPE had a capacity to induce VEGF production in human dental pulp cells. These findings suggest that CAPE might be useful as a novel biological material for the vital pulp therapy.
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| Free Research Field |
歯科保存学
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| Academic Significance and Societal Importance of the Research Achievements |
歯髄を除去された歯は歯根破折のリスクが上昇するため、その長期的予後は必ずしも良好とはいえず、歯の喪失の原因につながることから、歯髄保護の重要性が謳われている。今回の研究で、プロポリスの生理活性物質であるCAPEはヒト歯髄細胞に対し、ケモカイン産生抑制作用とVEGF誘導作用があることが明らかになった。したがって、CAPEを歯髄炎治療に応用することで、過剰な炎症反応を抑制し、組織修復を誘導させる作用が期待され、新規歯髄保護療法開発につながっていく可能性が示唆された。
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