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2012 Fiscal Year Final Research Report

Studies on cell functions regulated by changes in membrane phospholipid asymmetry

Research Project

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Project/Area Number 21370085
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionHokkaido University

Principal Investigator

TANAKA Kazuma  北海道大学, 遺伝子病制御研究所, 教授 (60188290)

Project Period (FY) 2009 – 2012
Keywords生体膜 / 脂質の非対称性 / フリッパーゼ / 細胞内小胞輸送 / 酵母
Research Abstract

Lipids are essential components of cell membranes. Abnormal distribution or transport of lipids is related to diseases, but much remains to be learned. In this study, we focus on phospholipid flippases, which transport phospholipids to the cytoplasmic leaflet of membranes, and have shown that flippases are involved in protein sorting and vesicle formation. We have also identified new genes that regulate phospholipid asymmetry of intracellular membranes.

  • Research Products

    (25 results)

All 2013 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (17 results)

  • [Journal Article] Identification of a second amphipathic lipid-packing sensor like motif that contributes to Gcs1p function in the early endosome-to-TGN pathway2013

    • Author(s)
      Zahra Zendeh-boodi, Takaharu Yamamoto, Hiroshi Sakane, and Kazuma Tanaka
    • Journal Title

      J Biochem

      Volume: 153 Pages: 573-587

    • DOI

      doi:10.1093/jb/mvt025.

    • Peer Reviewed
  • [Journal Article] Phospholipid flippases Lem3p-Dnf1p and Lem3p-Dnf2p are involved in the sorting of the tryptophan permease Tat2p in yeast2013

    • Author(s)
      Hachiro T, Yamamoto T, Nakano K, Tanaka K
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 3594-3608

    • DOI

      doi:10.1074/jbc.M112.416263.

    • Peer Reviewed
  • [Journal Article] Mutations in the N-terminal flanking region of the blue-light sensing domain LOV2 disrupt its repressive activity on the kinase domain in the Chlamydomonas phototropin2012

    • Author(s)
      Aihara Y, Yamamoto T, Okajima K, Yamamoto K, Suzuki T, Tokutomi S, Tanaka K, Nagatani A
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 9901-9909

    • DOI

      doi:10.1074/jbc.M111.324723.

    • Peer Reviewed
  • [Journal Article] Essential Role of the NH2-Terminal Region of Cdc24 Guanine Nucleotide Exchange Factor in Its Initial Polarized Localization in Saccharomyces cerevisiae2012

    • Author(s)
      Fujimura-Kamada K, Hirai T, Tanaka K
    • Journal Title

      Eukaryot Cell

      Volume: 11 Pages: 2-15

    • DOI

      doi:10.1128/EC.05146-11.

    • Peer Reviewed
  • [Journal Article] Isolation and characterization of novel mutations in CDC50,the non-catalytic subunit of the Drs2p phospholipid flippase2012

    • Author(s)
      Takahashi Y, Fujimura-Kamada K, Kondo S, and Tanaka K
    • Journal Title

      J Biochem

      Volume: 149 Pages: 423-432

    • DOI

      doi:10.1093/jb/mvq155.

    • Peer Reviewed
  • [Journal Article] Konomi Fujimura-Kamada and Takaharu YamamotoFunctions of phospholipid flippases2011

    • Author(s)
      Kazuma Tanaka
    • Journal Title

      J Biochem

      Volume: 149 Pages: 131-143

    • DOI

      doi:10.1093/jb/mvq140.

    • Peer Reviewed
  • [Journal Article] 出芽酵母の細胞極性形成における エンドサイトーシス-リサイクリング経路の役割アクチンケーブルが形成されない変異株からわかったこと2011

    • Author(s)
      山本隆晴,田中一馬
    • Journal Title

      化学と生物

      Volume: 49 Pages: 231-233

    • Peer Reviewed
  • [Journal Article] Initial polarized bud growth byendocytic recycling in the absence of actin cable-dependent vesicle transport in yeast2010

    • Author(s)
      Yamamoto T, Mochida J, Kadota J, Takeda M, Bi E, and Tanaka K
    • Journal Title

      Mol Biol Cell

      Volume: 21 Pages: 1237-1252

    • DOI

      doi:10.1091/mbc.E09-05-0412.

    • Peer Reviewed
  • [Presentation] エンドサイトーシスーリサイクリング経路におけるアレスチン様タンパク質Art5pとDnf1/2pリン脂質フリッパーゼとの相互作用2012

    • Author(s)
      山神香菜子,山本隆晴,武田美代子,湯田彬子,田中一馬
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2012-12-16
  • [Presentation] Isolation and characterization of novel mutations in CDC50, thenon-catalyticsubunit ofthe Drs2p phospholipid flippase.2012

    • Author(s)
      Konomi Fujimura-Kamada, Yasuhiro Takahashi, Satoshi Kondo, and Kazuma Tanaka
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      マリンメッセ福岡
    • Year and Date
      2012-12-15
  • [Presentation] 細胞内小胞輸送におけるリン脂質フリッパーゼの役割2011

    • Author(s)
      山本隆晴,鎌田このみ,花松久寿,ZahraZendehboodi,武田美代子,田中一馬
    • Organizer
      第48回日本生化学会北海道支部例会
    • Place of Presentation
      札幌医科大学記念ホール
    • Year and Date
      2011-08-05
  • [Presentation] 膜輸送におけるリン脂質フリッパーゼの役割2011

    • Author(s)
      山本隆晴,鎌田このみ,田中一馬
    • Organizer
      第63回細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-28
  • [Presentation] The Role of Phospholipid Asymmetry in Vesicle Transport in the Early Endosome-to-TGN Retrieval Pathway.2011

    • Author(s)
      武田美代子,山本隆晴,田中一馬
    • Organizer
      第63回細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-27
  • [Presentation] Functions of the non-catalytic region of Gcs1p in the phospholipid flippase- regulatingmembranetrafficking pathway2011

    • Author(s)
      Zahra Zendehboodi,Takaharu Yamamoto,Kazuma Tanaka
    • Organizer
      第63回細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-27
  • [Presentation] The role of phospholipid asymmetry in the localization of tryptophan permease Tat2p.2011

    • Author(s)
      鉢呂健,山本隆晴,田中一馬
    • Organizer
      第63回細胞生物学会大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2011-06-27
  • [Presentation] 細胞膜ホスファチジルセリン非対称性はどのように形成されるのか?2010

    • Author(s)
      三岡哲生,鎌田このみ,田中一馬
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
  • [Presentation] Yeast phospholipid translocase Drs2- Cdc50 functions with an F-boxprotein Rcy1 in endocytic recycling.2010

    • Author(s)
      花松久寿,鎌田このみ,田中一馬
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
  • [Presentation] Roles of phospholipid flippases and their related ArfGAP for protein trafficking.2010

    • Author(s)
      Takaharu Yamamoto, Takeru Hachiro, Zahra Zendehboodi, Kazuma Tanaka
    • Organizer
      The 27th NAITO CONFERENCE on MembraneDynamics and Lipid Biology [I]
    • Place of Presentation
      シャトレーゼガトーキングダム札幌
    • Year and Date
      2010-07-02
  • [Presentation] The functional analysis of phospholipid flippase in endocytic recycling.2010

    • Author(s)
      Konomi Fujimura-Kamada, Hisatoshi Hanamatsu, Koji Saito, Eno Shioji, Rosa Suzuki, Kazuma Tanaka
    • Organizer
      The 27th NAITO CONFERENCE on MembraneDynamics and Lipid Biology [I]
    • Place of Presentation
      シャトレーゼガトーキングダム札幌
    • Year and Date
      2010-07-02
  • [Presentation] Regulation and functional significance of phospholipid asymmetry.2010

    • Author(s)
      Kazuma Tanaka
    • Organizer
      The 27th NAITO CONFERENCE on MembraneDynamics and Lipid Biology [I].
    • Place of Presentation
      シャトレーゼガトーキングダム札幌
    • Year and Date
      2010-07-01
  • [Presentation] Roles of phospholipid flippases and their related ArfGAP for protein trafficking.2010

    • Author(s)
      Takaharu Yamamoto, Takeru Hachiro, Zahra Zendehboodi, Kazuma Tanaka
    • Organizer
      Sapporo International Cancer Symposium2010.
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-06-28
  • [Presentation] The functional analysis of phospholipid flippase in endocytic recycling.2010

    • Author(s)
      Konomi Fujimura-Kamada, Hisatoshi Hanamatsu, Koji Saito, Eno Shioji, Rosa Suzuki, Kazuma Tanaka
    • Organizer
      Sapporo International Cancer Symposium2010.
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-06-28
  • [Presentation] 膜脂質非対称性の制御機構と細胞機能2010

    • Author(s)
      田中一馬
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-30
  • [Presentation] フリッペースが制御する膜脂質非対称性とその細胞機能2009

    • Author(s)
      田中一馬
    • Organizer
      第82回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-10-24
  • [Presentation] Cellular functions of phospholipid Flippases.2009

    • Author(s)
      Kazuma Tanaka
    • Organizer
      The fourth iCeMS International Symposium
    • Place of Presentation
      ホテルフジタ京都
    • Year and Date
      2009-05-28

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Published: 2014-08-29  

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