2011 Fiscal Year Final Research Report
Screening of sporozoite receptor molecule(s) on hepatocytes
| Project/Area Number |
21390124
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Parasitology (including Sanitary zoology)
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
TORII Motomi 愛媛大学, 大学院・医学系研究科, 教授 (20164072)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMOKO Ishino 愛媛大学, 大学院医学系研究科, 准教授 (40402680)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | マラリア原虫 / スポロゾイト / 細胞侵入 |
|---|
| Research Abstract |
Characterization of P36p, the sporozoite secreted proteins involved in hepatocyte infection, was performed using monoclonal antibody. It was revealed that P36p starts expression after sporozoites released into hemolymph and stored in microneme, the apical organelle, until they are secreted before or during hepatocyte invasion. Moreover, 6 rhoptry molecules commonly expressed in target cell infective stages(merozoite and sporozoites) were identified.
|
