Molecular anlysis and development of targeting therapy in pediatric solid tumors by use of whole genomic and epigenomic resolution

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390316
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Gunma Institute of Public Health and Environmental Sciences
• Principal Investigator: HAYASHI Yasuhide 群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
• Co-Investigator(Kenkyū-buntansha): SOTOMATSU Manabu 群馬県衛生環境研究所, 研究企画係, 研究員 (70251113) ; PARK Myoung-ja 群馬県衛生環境研究所, 研究企画係, 研究員 (50450375) ; OHKI Kentaro 群馬県衛生環境研究所, 研究企画係, 研究員 (50400966)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Seishi 東京大学, 医学部・附属病院, 特任教授 (60292900)
• Project Period (FY): 2009 – 2011
• Keywords: 小児腫瘍学

Research Abstract

Partial deficient ALK was found to be involved in tumorigenesis of neuroblastoma(NB), and novel activating mutations of ALK gene were found in Ewing Sarcoma. High expression of ALK gene was found in 50 cases with rhabdomyosarcoma. Aberrations of ILD1 and 2 genes were found in 4 pediatric tumors including NB. Furthermore, exome analysis using next generation sequencer and analysis of ALK pathway-related genes revealed several new aberrations in NB, suggesting that ALK pathway plays an important role in the development and advance of neuroblastoma and could be molecular target for treatment.

Research Products

• [Journal Article] RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse : a study of the Japanese Childhood AML Cooperative Study Group (2012)
  • Author(s): Sano H, Shimada A, Taki T, Murata C, Park MJ, Sotomatsu M, Tabuchi K, Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y.
  • Journal Title: Int J Hematol Volume: 95 Pages: 509-515
  • DOI: DOI:10.1007/s12185-012-1033-x
  • Peer Reviewed
• [Journal Article] Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia (2012)
  • Author(s): Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park MJ, Kanno Y, Takahara T, Yamazaki Y, Ito E, Hayashi Y, Nakamura T.
  • Journal Title: Blood Volume: 119 Pages: 2608-2611
  • DOI: DOI:10.1182/blood-2010-12-324806
  • Peer Reviewed
• [Journal Article] CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (2012)
  • Author(s): Shiba N, Hasegawa D, Park MJ, Murata C, Matsubara A, Ogawa C, Manabe A, Arakawa H, Ogawa S, Hayashi Y.
  • Journal Title: Blood Volume: 119 Pages: 2612-2614
  • DOI: DOI:10.1182/blood-2011-02-333435
  • Peer Reviewed
• [Journal Article] Clinical significance of early T-cell precursor acute lymphoblastic leukaemia : Results of the Tokyo Children's Cancer Study Group Study L99-15 (2012)
  • Author(s): Inukai T, Kiyokawa N, Campana D, Coustan-Smith E, Kikuchi A, Kobayashi M, Takahashi H, Koh K, Manabe A, Kumagai M, Ikuta K, Hayashi Y, Tsuchida M, Sugita K, Ohara A.
  • Journal Title: Brit J Haematol Volume: 156 Pages: 358-365
  • DOI: DOI:10.1111/j.1365-2141.2011.08955.x
  • Peer Reviewed
• [Journal Article] DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia (2012)
  • Author(s): Shiba N, Taki T, Park MJ, Shimada A, Sotomatsu M, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y.
  • Journal Title: Br J Haematol Volume: 156 Pages: 413-414
  • DOI: DOI:10.1111/j.1365-2141.2011.08879.x
  • Peer Reviewed
• [Journal Article] CBL mutations in infant acute lymphoblastic leukaemia (2012)
  • Author(s): Shiba N, Park MJ, Taki T, Takita J, Hiwatari M, Kanazawa T, Sotomatsu M, Ishii E, Arakawa H, Ogawa S, Hayashi Y.
  • Journal Title: Br J Haematol Volume: 156 Pages: 672-674
  • DOI: DOI:10.1111/j.1365-2141.2011.08900.x
  • Peer Reviewed
• [Journal Article] Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma (2011)
  • Author(s): Takita J, Chen Y, Okubo J, Sanada M, Adachi M, Ohki K, Nishimura R, Hanada R, Igarashi T, Hayashi Y, Ogawa S.
  • Journal Title: Cancer Sci Volume: 102 Pages: 1645-1650
  • DOI: DOI:10.1111/j.1349-7006.2011.01995.x
  • Peer Reviewed
• [Journal Article] CBL mutation in childhood therapy-related leukemia (2011)
  • Author(s): Shiba N, Taki T, Park MJ, Nagasawa M, Kanazawa T, Takita J, Ohnishi H, Sotomatsu M, Arakawa H, Hayashi Y.
  • Journal Title: Leukemia Volume: 25 Pages: 1356-1358
  • DOI: DOI:10.1038/leu.2011.75
  • Peer Reviewed
• [Journal Article] Chromosome abnormalities in advanced stage T-cell lymphoblastic lymphoma of children and adolescents : a report from Japanese Paediatric Leukaemia/Lymphoma Study Group(JPLSG) and review of the literature (2011)
  • Author(s): Sekimizu M, Sunami S, Nakazawa A, Hayashi Y, Okimoto Y, Saito AM, Horibe K, Tsurusawa M, Mori T.
  • Journal Title: Br J Haematol Volume: 154 Pages: 612-617
  • DOI: DOI:10.1111/j.1365-2141.2011.08788.x
  • Peer Reviewed
• [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies (2011)
  • Author(s): Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Journal Title: Leukemia Volume: 25 Pages: 382-384
  • DOI: DOI:10.1038/leu.2010.307
  • Peer Reviewed
• [Journal Article] Oncogenic mutations of ALK in neuroblastoma (2011)
  • Author(s): Ogawa S, Takita J, Sanada M, Hayashi Y.
  • Journal Title: Cancer Science Volume: 102 Pages: 302-308
  • DOI: DOI:10.1111/j.1349-7006.2010.01825.x
  • Peer Reviewed
• [Journal Article] FLT3-internal tandem duplication, CD56 expression, and obstructive jaundice due to granulocytic sarcoma at relapse in a pediatric patient with t(8 ; 21) acute myeloid leukemia (2010)
  • Author(s): Kawamura M, Kaku H, Ito T, Funata N, Taki T, Shimada A, Hayashi Y.
  • Journal Title: Cancer Genet Cytogenet Volume: 203 Pages: 292-296
  • DOI: 10.1016/j.cancergencyto.
  • Peer Reviewed
• [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome (2010)
  • Author(s): Seki M, Kimura H, Mori A, Shimada A, Yamada Y, Maruyama K, Hayashi Y, Agematsu K, Morio T, Yachie A, Kato M.
  • Journal Title: Pediatr Int Volume: 52 Pages: e196-199
  • DOI: DOI:10.1111/j.1442-200X.2010.03135.x
  • Peer Reviewed
• [Journal Article] High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes (2010)
  • Author(s): Taketani T, Taki T, Nakamura T, Kobayashi Y, Ito E, Fukuda S, Yamaguchi S, Hayashi Y.
  • Journal Title: Leukemia Volume: 24 Pages: 1975-1977
  • DOI: DOI:10.1038/leu.2010.207
  • Peer Reviewed
• [Journal Article] NOTCH1 mutation in a female with myeloid/NK cell precursor acute leukemia (2010)
  • Author(s): Shiba N, Kanazawa T, Park MJ, Okuno H, Tamura K, Tsukada S, Hayashi Y, Arakawa H.
  • Journal Title: Pediatr Blood Cancer Volume: 55 Pages: 1406-1409
  • DOI: DOI:10.1002/pbc.22758
  • Peer Reviewed
• [Journal Article] Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder : mutation classes correlate with progression to myeloid leukemia (2010)
  • Author(s): Kanezaki R, Toki T, Terui K, Xu G, Wang R, Shimada A, Hama A, Kanegane H, Kawakami K, Endo M, Hasegawa D, Kogawa K, Adachi S, Ikeda Y, Iwamoto S, Taga T, Kosaka Y, Kojima S, Hayashi Y, Ito E.
  • Journal Title: Blood Volume: 116 Pages: 4631-4638
  • DOI: DOI:10.1182/blood-2010-05-282426
  • Peer Reviewed
• [Journal Article] Expression of ADAMTS4 in Ewing's sarcoma (2010)
  • Author(s): Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura T, Nosaka T.
  • Journal Title: Int J Oncol Volume: 37 Pages: 569-581
  • DOI: DOI:10.3892/ijo_00000706
  • Peer Reviewed
• [Journal Article] Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype : a study by the Japanese Childhood AML Cooperative Study Group (2010)
  • Author(s): Mizushima Y, Taki T, Shimada A, Yui Y, Hiraumi Y, Matsubara H, Watanabe M, Watanabe K, Kamitsuji Y, Hayashi Y, Tsukimoto I, Kobayashi R, Horibe K, Tawa A, Nakahata T, Adachi S.
  • Journal Title: Int J Hematol Volume: 91 Pages: 831-837
  • DOI: DOI:10.1007/s12185-010-0585-x
  • Peer Reviewed
• [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model (2010)
  • Author(s): Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T.
  • Journal Title: Leukemia Volume: 24 Pages: 1018-1024
  • DOI: doi:10.1038/leu.2010.40
  • Peer Reviewed
• [Journal Article] Tokyo Children's Cancer Study Group. Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia (2010)
  • Author(s): Tsuchida M, Ohara A, Manabe A, Kumagai M, Shimada H, Kikuchi A, Mori T, Saito M, Akiyama M, Fukushima T, Koike K, Shiobara M, Ogawa C, Kanazawa T, Noguchi Y, Oota S, Okimoto Y, Yabe H, Kajiwara M, Tomizawa D, Ko K, Sugita K, Kaneko T, Maeda M, Inukai T, Goto H, Takahashi H, Isoyama K, Hayashi Y, Hosoya R, Hanada R
  • Journal Title: Leukemia Volume: 24 Pages: 383-396
  • DOI: DOI:10.1038/leu.2009.260
  • Peer Reviewed
• [Journal Article] CBL mutations in juvenile myelomonocytic leukemia and pediatric myelodysplastic syndrome (2010)
  • Author(s): Shiba N, Kato M, Park MJ, Sanada M, Ito E, Fukushima K, Sako M, Arakawa H, Ogawa S, Hayashi Y.
  • Journal Title: Leukemia Volume: 24 Pages: 1090-1092
  • DOI: DOI:10.1038/leu.2010.49
  • Peer Reviewed
• [Journal Article] Mixed-lineage-leukemia(MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation (2009)
  • Author(s): Ono R, Kumagai H, Nakajima H, Hishiya A, Taki T, Horikawa K, Takatsu K, Satoh T, Hayashi Y, Kitamura T, Nosaka T.
  • Journal Title: Leukemia Volume: 23 Pages: 2197-2209
  • DOI: DOI:10.1038/leu.2009.177
  • Peer Reviewed
• [Journal Article] Manifestation of alveolar rhabdomyosarcoma as primary cutaneous lesions in a neonate with Beckwith-Wiedemann syndrome (2009)
  • Author(s): Kuroiwa M, Sakamoto J, Shimada A, Suzuki N, Hirato J, Park MJ, Sotomatsu M, Hayashi Y.
  • Journal Title: J Pediatr Surg Volume: 44 Pages: 31-35
  • DOI: DOI:10.1016/j.jpedsurg.2008.12.010
  • Peer Reviewed
• [Journal Article] JAK2V617F mutation-positive childhood essential thrombocythemia associated with cerebral venous sinus thrombosis (2009)
  • Author(s): Kurosawa H, Okuya M, Matsushita T, Kubota T, Endoh K, Kuwashima S, Hagisawa S, Sato Y, Fukushima K, Sugita K, Okada Y, Park MJ, Hayashi Y, Arisaka O.
  • Journal Title: J Pediatr Hematol Oncol Volume: 31 Pages: 678-680
  • DOI: DOI:10.1097/MPH.0b013e3181b1ec9e
  • Peer Reviewed
• [Journal Article] Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms (2009)
  • Author(s): Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
  • Journal Title: Nature Volume: 460 Pages: 904-908
  • DOI: DOI:10.1038/nature08240
  • Peer Reviewed
• [Journal Article] Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene (2009)
  • Author(s): Takita J, Motomura A, Koh K, Ida K, TakiT, Hayashi Y, Igarashi T.
  • Journal Title: Eur J Haematol Volume: 83 Pages: 149-153
  • DOI: DOI:10.1111/j.1600-0609.2009.01275.x
  • Peer Reviewed
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas (2009)
  • Author(s): Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S.
  • Journal Title: Nature Volume: 459 Pages: 712-716
  • DOI: DOI:10.1038/nature07969
  • Peer Reviewed
• [Journal Article] NUP98-NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8 ; 11)(p11 ; p15) and expression pattern of NSD family genes (2009)
  • Author(s): Taketani T, Taki T, Nakamura H, Taniwaki M, Masuda J, Hayashi Y.
  • Journal Title: Cancer Genet Cytogenet Volume: 190 Pages: 108-112
  • DOI: DOI:10.1016/j.cancergencyto.2008.12.008
  • Peer Reviewed
• [Journal Article] Possible involvement of RasGRP4 in leukemogenesis (2009)
  • Author(s): Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R, Harada Y, Harada H, Hayashi Y, Nakajima H, Nosaka T, Kitaura J, Kitamura T.
  • Journal Title: Int J Hematol Volume: 89 Pages: 470-481
  • DOI: DOI:10.1007/s12185-009-0299-0
  • Peer Reviewed
• [Journal Article] Juvenile myelomonocytic leukemia with t(7 ; 11)(p15 ; p15) and NUP98-HOXA11 fusion (2009)
  • Author(s): Mizoguchi Y, Fujita N, Taki T, Hayashi Y, Hamamoto K.
  • Journal Title: Am J Hematol Volume: 84 Pages: 295-297
  • DOI: DOI:10.1002/ajh.21373
  • Peer Reviewed
• [Journal Article] FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma (2009)
  • Author(s): Park MJ, Taki T, Oda M, Watanabe T, Yumura-Yagi K, Kobayashi R, Suzuki N, Hara J, Horibe K, Hayashi Y.
  • Journal Title: Brit J Haematol Volume: 145 Pages: 198-206
  • DOI: DOI:10.1111/j.1365-2141.2009.07607.x
  • Peer Reviewed
• [Journal Article] Age-associated difference in gene expression of pediatric acute myelomonocytic lineage leukemia(FAB M4 and M5 subtypes) and its correlation with prognosis (2009)
  • Author(s): Jo A, Tsukimoto I, Ishii E, Asou N, Mitani S, Shimada A, Igarashi T, Hayashi Y, Ichikawa H.
  • Journal Title: Brit J Haematology Volume: 144 Pages: 917-929
  • DOI: DOI:10.1111/j.1365-2141.2008.07531.x
  • Peer Reviewed
• [Journal Article] Transient abnormal myelopoiesis in a Down syndrome newbornfollowed by acute myeloid leukemia : identification of the same chromosomal abnormality in both stages (2009)
  • Author(s): Kitoh T, Taki T, Hayashi Y, Nakamura K, Irino T, Osaka M.
  • Journal Title: Cancer Genet Cytogenet Volume: 188 Pages: 99-102
  • DOI: DOI:10.1016/j.cancergencyto.2008.08.011
  • Peer Reviewed
• [Journal Article] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma
  • Author(s): Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S.
  • Journal Title: Oncogene Volume: (in press)
  • DOI: DOI:10.1038/onc.2011.616.
  • Peer Reviewed
• [Journal Article] Novel splicing factor mutations in juvenile myelomonocytic leukemia
  • Author(s): Takita J, Yoshida K, Sanada M, Nishimura R, Okubo J, Motomura A, Hiwatari M, Oki K, Igarashi T, Hayashi Y, Ogawa S.
  • Journal Title: Leukemia Volume: (in press)
  • DOI: DOI:10.1038/onc.2011.616.
  • Peer Reviewed
• [Presentation] 再発後にMLL-AF4陽性となったB前駆型急性リンパ性白血病の1例 (2012)
  • Author(s): 大木健太郎,朴明子,外松学,林泰秀
  • Organizer: 日本血液学会第167回例会
  • Place of Presentation: 東京
  • Year and Date: 2012-03-03
• [Presentation] NUP98-NSD1 fusion gene is strongly associated with a poor prognosis in pediatric acute myeloid leukemia : a study of the Japanese Childhood AML99 Cooperative Study Group (2011)
  • Author(s): Shiba N, Taki T, Park M, Murata C, Oki K, Ichikawa H, Shimada A, Kanazawa T, Sotomatsu M, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y.
  • Organizer: 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego
  • Year and Date: 20111209-13
• [Presentation] The Concurrent mutations in hematological malignancies with NUP98-fusion genes are associated with clinical prognosis (2011)
  • Author(s): Taketani T, Taki T, Fukuda S, Hyuga M, Onishi C, Yamaguchi S, Hayashi Y.
  • Organizer: 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego
  • Year and Date: 20111209-13
• [Presentation] JAK2 mutations and CRLF2 rearrangements in down syndrome associated acute lymphoblastic leukemia in Japan (2011)
  • Author(s): Hanada I, Terui K, Toki T, Kudo K, Sato T, Kamio T, Sasaki S, Takahashi Y, Hayashi Y, Sugita K, Kojima S, Koike K, Kosaka Y, Kobayashi M, Ito E.
  • Organizer: 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego
  • Year and Date: 20111209-13
• [Presentation] Heterogeneity in infants with acute myeloid leukemia : retrospective analysis of a Japanese nationwide survey (2011)
  • Author(s): Shimada A, Tomizawa D, Kinoshita A, Hamamoto K, Tsukimoto I, Ogawa A, Taga T, Imamura T, Tawa A, Horibe K, Taki T, Hayashi Y, Adachi S.
  • Organizer: 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego
  • Year and Date: 20111209-13
• [Presentation] GATA1 mutants lacking Rb-binding motif observed in transient abnormal myelopoiesis in down syndrome (2011)
  • Author(s): Toki T, Kobayashi E, Kanezaki R, Wang RN, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adach S, Hayashi Y, Shimizu R, Yamamoto M, Ito E.
  • Organizer: 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego
  • Year and Date: 20111209-13
• [Presentation] TCCSG小児B前駆細胞型急性リンパ性白血病におけるCRLF2とIKZF1の解析 (2011)
  • Author(s): 大木健太郎,大喜多肇,小林健一郎,清河信敬,朴明子,新井心,外松学,柴徳生,福島敬,康勝好,花田良二,真部淳,菊地陽,小原明,土田昌宏,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] ダウン症候群関連ALLの発症におけるJAK2、およびCRLF2遺伝子異常の解析 (2011)
  • Author(s): 花田勇,照井君典,土岐力,工藤耕,佐藤知彦,神尾卓哉,佐々木伸也,高橋良博,林泰秀,杉田完爾,小島勢二,小池健一,小阪嘉之,小林正夫,伊藤悦朗
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] Gene expression profiles of early T-cell precursor(ETP-) ALL and T-ALL treated in TCCSG trials (2011)
  • Author(s): 清河信敬,林泰秀,小原明
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] 小児ALL関連キメラ遺伝子発現量の抹消血中推移と既知リスク因子との関連について (2011)
  • Author(s): 福島敬,南木融,清河信敬,小林千恵,福島紘子, Mahmoud Shaza,康勝好,菊地陽,真部淳,熊谷昌明,土田昌宏,林泰秀,小原明
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] 小児固形腫瘍組織におけるI型インスリン様増殖因子受容体(IGF-1R) (2011)
  • Author(s): 若井公子,大木健太郎,朴明子,外松学,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] t(9 ; 17)(p24 ; q23)を伴うJAK2遺伝子関連急性リンパ性白血病の遺伝子解析 (2011)
  • Author(s): 川村眞智子,賀来秀文,小野敏明,田渕健,荒木聡,滝智彦,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] 再発後にMLL-AF4陽性となったBCP-ALLの一例 (2011)
  • Author(s): 奥野はるな、金澤崇,柴徳生,朴明子,外松学,神谷尚宏,小川千登世,林泰秀,荒川浩一
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] 小児固形腫瘍におけるIDH 1/2変異の解析 (2011)
  • Author(s): 大久保淳,大木健太郎,滝田順子,樋渡光輝,西村力,真田昌,佐藤香織,五十嵐香織,林泰秀,曽我朋義,小川誠司,五十嵐隆
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] ASPL-TFE3キメラ遺伝子にて診断確定を得た膣原発alveolar soft part sarcomaの一例 (2011)
  • Author(s): 新井心,朴明子,大木健太郎,外松学,土岐文彰,山本英輝,西明,鈴木則夫,畠山信逸,中村和人,平戸純子,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-27
• [Presentation] 次世代シークエンサによる神経芽腫のエクソーム解析 (2011)
  • Author(s): 西村力,滝田順子,吉田健一,白石友一,川幡亮一郎,永田安伸,大久保淳,真田昌,林泰秀,五十嵐隆,宮野悟,小川誠司
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-26
• [Presentation] 小児急性白血病におけるDNMT3A遺伝子変異の解析 (2011)
  • Author(s): 柴徳生,朴明子,村田知里,嶋田明,滝智彦,外松学,田渕健,足立壮一,多和昭雄,堀部敬三,土田昌宏,花田良二,月本一郎,荒川浩一,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] 小児急性骨髄性白血病におけるNUP98-NSD転座の解析 (2011)
  • Author(s): 柴徳生,朴明子,村田知里,嶋田明,滝智彦,外松学,田渕健,足立壮一,多和昭雄,堀部敬三,土田昌宏,花田良二,月本一郎,荒川浩一,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] 染色体11p15異常を有する造血器腫瘍における遺伝子変異と臨床像の関連 (2011)
  • Author(s): 竹谷健,滝智彦,日向瑞貴,安部真理子,福田誠司,山口清次,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] 東京小児がんグループ(TCCSG) ALL治療研究登録症例の網羅的遺伝子発現解析 (2011)
  • Author(s): 飯島一智,清河信敬,小林健一郎,大喜多肇,山田浩之,三春昌嗣,森鉄也,福島敬,南木融,斎藤正博,康勝好,真部淳,菊地陽,熊谷昌明,藤本純一郎,林泰秀,土田昌宏,小原明
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] TCCSG ALL登録症例の細胞抗原とキメラ遺伝子との関連性についての検討 (2011)
  • Author(s): 小林健一郎,福島敬,南木融,清河信敬,三春昌嗣,山田浩之,飯島一智,大喜多肇,森鉄也,熊谷昌明,藤本純一郎,斎藤正博,康勝好,真部淳,菊地陽,林泰秀,土田昌宏,小原明
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] T細胞型小児急性リンパ性白血病における遺伝子異常の解析 (2011)
  • Author(s): 朴明子,清河信敬,小田慈,真部淳,原純一,小原明,花田良二,土田昌宏,小川誠司,堀部敬三,林泰秀
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] MLL再構成陽性の小児急性リンパ性白血病のエクソーム解析 (2011)
  • Author(s): 堤修一,王凌華,朴明子,照井君典,佐々木伸也,伊藤悦朗,林泰秀,油谷浩幸
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] 乳児白血病におけるIDH1およびIDH2遺伝子の解析 (2011)
  • Author(s): 樋渡光輝,大木健太郎,滝田順子,西村力,真田昌,大久保淳,外松学,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] ダウン症候群に合併した一過性骨髄増殖症(TAM)および急性巨核芽球性白血病(AMKL)の全エクソンシーケンス (2011)
  • Author(s): 吉田健一,土岐力,朴明子,永田安伸,王汝南,白石友一,真田昌,昆彩菜,佐藤亜依子,長崎正朗,宮野悟,金兼弘和,川上清,加藤剛二,小島勢二,林泰秀,伊藤悦朗,小川誠司
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] CBL mutation in CMML secondary to familial platelet disorder with propensity to develop AML (2011)
  • Author(s): Shiba N, Hasegawa D, Park MJ, Murata C, Matsubara A, Ogawa C, Manabe A, Arakawa H, Ogawa S, Hayashi Y.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Clinical significance of ETP-ALL in childhood T-ALL ; the TCCSG L99-15 study (2011)
  • Author(s): Inukai T, Kiyokawa N, Ohara A, Takahashi H, Koh K, Manabe A, Kumagai M, Ikuta K, Hayashi Y, Tsuchida M, Campana D, Sugita K.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Molecular characteristics of early T-cell precursor(ETP) ALL and T-ALL treated in TCCSG trials (2011)
  • Author(s): Kiyokawa N, Iijima K, Inukai T, Takahashi H, Fukushima T, Koh Y, Sugita K, Manabe A, Kikuchi A, Kumagai M, Ohara A, Fujimoto J, Hayashi Y.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Novel GATA1 mutants with internal deletions in transient abnormal myelopoiesis in down syndrome (2011)
  • Author(s): Toki T, Kobayashi E, Kanezaki R, Wang R, Terui K, Kanegane H, Maeda M, Koike T, Endo M, Adachi S, Hayashi Y, Shimizu R, Yamamoto M, Ito E.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Whole exome analysis of transient abnormal myelopoiesis and acute megakaryocytic leukemia with Down syndrome (2011)
  • Author(s): Yoshida K, Toki T, Park MJ, Nagata Y, Wang R, Shiraishi Y, Sanada M, Nagasaki M, Miyano S, kanegane H, Kawakami K, Kato K, Hayashi Y, Ito E, Ogawa S.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Aberrations of DNMT3A in pediatric myeloid malignancies (2011)
  • Author(s): Motomura A, Oki K, Takita J, Nishimura R, Okubo J, Hiwatari M, Sanada M, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] The clinical significance of LEF1 mutation in childhood acute lymphblastic leukemia (2011)
  • Author(s): Park MJ, Kiyokawa N, Oda M, Manabe A, Hara J, Ohara A, Hanada R, Tsuchida M, Ogawa S, Horibe K, Hayashi Y.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-15
• [Presentation] Mutation analysis for IDH1 and IDH2 in infantile leukemia (2011)
  • Author(s): Hiwatari M, Ohki K, Takita J, Nishimura R, Sanada M, Okubo J, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] 次世代シーケンサーによる神経芽腫のエクソーム解析 (2011)
  • Author(s): 西村力,滝田順子,吉田健一,白石友一,川幡亮一郎,永田安伸,大久保淳,真田昌,五十嵐隆,林泰秀,宮野悟,小川誠司
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] 小児T細胞性急性リンパ性白血病におけるLEF1遺伝子の異常と臨床像について (2011)
  • Author(s): 朴明子,清河信敬,小田慈,真部淳,小原明,花田良二,土田昌宏,小川誠司,堀部敬三,林泰秀
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] 小児固形腫瘍におけるIDH変異の解析 (2011)
  • Author(s): 大久保淳,大木健太郎,滝田順子,樋渡光輝,西村力,真田昌,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] 乳児白血病におけるIDH 1/2遺伝子の変異解析 (2011)
  • Author(s): 樋渡光輝,滝田順子,真田昌,西村力,大久保淳,井田孔明,外松学,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] MLL関連キメラが検出されないCD10陰性ALLのマーカーと発現遺伝子の特徴 (2011)
  • Author(s): 清河信敬,飯島一智,加藤元博,福島敬,康勝好,真部淳,菊地陽,熊谷昌明,藤本純一郎,林泰秀,小原明
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] 神経芽腫における部分欠損型ALKの造腫瘍性に関する検討 (2011)
  • Author(s): 大久保淳,滝田順子,大木健太郎,西村明,安達正時,加藤元博,真田昌,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-14
• [Presentation] 高密度SNPアレイを用いた胸膜肺芽腫における網羅的ゲノム解析 (2011)
  • Author(s): 大久保淳,滝田順子,大木健太郎,西村力,安達正時,真田昌,加藤啓輔,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-14
• [Presentation] 小児悪性腫瘍におけるIsocitrate dehydrogenase 1/2の変異解析 (2011)
  • Author(s): 大木健太郎,滝田順子,樋渡光輝,西村力,大久保淳,安達正時,外松学,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-14
• [Presentation] 治療関連白血病と乳児白血病におけるCBL遺伝子変異の解析 (2011)
  • Author(s): 柴徳生,滝智彦,朴明子,加藤元博,滝田順子,金澤崇,外松学,長澤正之,荒川浩一,林泰秀
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-13
• [Presentation] TCCSG登録例における小児ALL関連キメラ遺伝子発現量の推移について (2011)
  • Author(s): 福島敬,南木融,清河信敬,康勝好,真部淳,菊地陽,熊谷昌明,林泰秀,土田昌宏,小原明
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-13
• [Presentation] 10カラーフローサイトメトリー解析による小児白血病のマーカー診断 (2011)
  • Author(s): 清河信敬,山田浩之,康勝好,福島敬,真部淳,菊地陽,熊谷昌明,小原明,林泰秀,土田昌宏
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-13
• [Presentation] 革新的ゲノム解析技術を用いた難治性小児固形腫瘍における発症分子機構の解明 (2011)
  • Author(s): 滝田順子,西村力,安達正時,大木健太郎,大久保淳,樋渡光輝,真田昌,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-12
• [Presentation] 神経芽腫における全エクソン領域のシークエンス解析 (2011)
  • Author(s): 安達正時,滝田順子,西村力,真田昌,樋渡光輝,大木健太郎,大久保淳,林泰秀,五十嵐隆,小川誠司
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-12
• [Presentation] TAMにおける遺伝学的基盤探索 (2011)
  • Author(s): 小川誠司,加藤元博,林泰秀
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-12
• [Presentation] 次世代シークエンサーによる神経芽腫におけるエクソーム解析 (2011)
  • Author(s): 滝田順子,安達正時,西村力,吉田健一,小川誠司,林泰秀
  • Organizer: 第6回JNBSG研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-30
• [Presentation] Aberrant activation of ALK kinase by a short form ALK protein in neuroblastoma (2010)
  • Author(s): Okubo J, Takita J, Nishimura R, Oki K, Kato M, Chen Y, Sanada M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: Advances in Neuroblastoma Research
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100621-24
• [Presentation] Effects of selective ALK inhibitors to neuroblastoma. (2010)
  • Author(s): Takita J, Okubo J, Nishimura R, Oki K, Uchisaka N, Chen Y, Sanada M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: Advances in Neuroblastoma Research
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20100621-24
• [Presentation] T細胞性急性リンパ性白血病におけるLEF1遺伝子異常の解析 (2010)
  • Author(s): 朴明子,清河信敬,加藤元博,鈴木信寛,小田慈,原純一,小林良二,小川誠司,堀部敬三,林泰秀
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-19
• [Presentation] 急性骨髄性白血病におけるRAS遺伝子変異と臨床像 (2010)
  • Author(s): 佐野弘純,嶋田明,村田知里,朴明子,外松学,滝智彦,田渕健,多和昭雄,堀部敬三,土田昌宏,花田良二,月本一郎,林泰秀
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-18
• [Presentation] 治療関連白血病におけるCBLとRAS遺伝子の解析 (2010)
  • Author(s): 柴徳生,滝智彦,朴明子,長澤正之,金澤崇,外松学,荒川浩一,林泰秀
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-18
• [Presentation] 次世代シークエンサーを用いたエクソンシークエンスによる神経芽腫の標的分子の解析 (2010)
  • Author(s): 吉田健一,滝田順子,西村力,安達正時,大木健太郎,大久保淳,永田安伸,真田昌,林泰秀,五十嵐隆,小川誠司
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-18
• [Presentation] 小児固形腫瘍におけるNOTCHシグナルの検討;発現様式と遺伝子変異の解析 (2010)
  • Author(s): 安達正時,滝田順子,樋渡光輝,西村力,大木健太郎,大久保淳,内坂直樹,真田昌,小川誠司,林泰秀,五十嵐隆
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-18
• [Presentation] 小児悪性腫瘍におけるIsocitrate depydrogenase 1/2の変異解析 (2010)
  • Author(s): 大木健太郎,滝田順子,樋渡光輝,西村力,大久保淳,安達正時,真田昌,外松学,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-18
• [Presentation] 小児固形腫瘍におけるALK遺伝子の解析 (2010)
  • Author(s): 西村力,滝田順子,大木健太郎,金兼弘和,大喜多肇,藤本純一郎,陳玉彦,真田昌,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-17
• [Presentation] 高密度SNPアレイを用いた胸膜肺芽腫における網羅的ゲノム解析 (2010)
  • Author(s): 大久保淳,滝田順子,大木健太郎,西村力,内坂直樹,安達正時,真田昌,加藤啓輔,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第52回日本小児血液学会総会・第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-17
• [Presentation] CBL mutations in therapy-related leukemia and infant leukemia (2010)
  • Author(s): Shiba N, Taki T, Park MJ, Nagasawa M, Takita J, Kato M, Kanazaw T, Sotomatsu M, Arakawa H, Hayashi Y.
  • Organizer: The 53rd ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando, U. S. A
  • Year and Date: 2010-12-07
• [Presentation] LEF1 gene mutations in childhood T-cell acute lymphoblastic leukemia and T cell non-hodgkin's lymphoma (2010)
  • Author(s): Park MJ, Kiyokawa N, Kato M, Suzuki N, Oda M, Hara J, Kobayashi R, Horibe K, Ogawa S, Hayashi Y.
  • Organizer: The 53rd ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando, U. S. A
  • Year and Date: 2010-12-06
• [Presentation] Low-dose cytosine arabinoside therapy for neonates with down syndrome(DS) and transient leukemia(TL) (2010)
  • Author(s): Muramatsu H, Hayashi Y, Kawamura M, Kojima S, Yabe M, Isoyama K, Taki T, Tsuji K, Tsuchida M, Manabe A, Ito E, Iwamoto S, Kato H, Sumie A, Taga T, Nomura K, Hasegawa D, Watanabe K, Kikuchi A.
  • Organizer: The 53rd ASH Annual Meeting and Exposition
  • Place of Presentation: Orlando, U. S. A
  • Year and Date: 2010-12-06
• [Presentation] Mutation analyses of CBL and MPL genes in childhood leukemia and myelodysplastic syndrome (2010)
  • Author(s): Shiba N, Kato M, Park MJ, Sanada M, Fukushima K, Kudo K, Hanada R, Ito E, Arakawa H, Ogawa S, Hayashi Y.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-26
• [Presentation] Mutation analysis of lymphocyte tyrosine kinase(LTK) in acute lymphoblastic leukemia (2010)
  • Author(s): Uchisaka N, Kato M, Takita J, Sanada M, Nishimura R, Oki K, Okubo J, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Genome-wide analysis using high-density SNP microarrays in various types of hematologic malignancies (2010)
  • Author(s): Matsubara A, Kato M, Sanada M, Takita J, Chiba S, Hayashi Y, Kobayashi Y, Watanabe T, Yoshino T, Koeffler JP, Bartram CR, Ogawa S.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Mutations of LEF1 gene in pediatric T cell acute lymphoblastic leukemia (2010)
  • Author(s): Park MJ, Kato M, Kiyokawa N, Takita J, Ogawa S, Hayashi Y.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] Internal deletions of transcription factor GATA1 observed in transient abnormal myelopoiesis (2010)
  • Author(s): Toki T, Kanezaki R, Wang RN, Terui K, Hayashi Y, Miura M, Maeda M, Ito E.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] 小児悪性造血腫瘍におけるCBL遺伝子とMPL遺伝子の変異解析 (2010)
  • Author(s): 柴徳生,加藤元博,朴明子,真田昌,花田良二,伊藤悦朗,荒川浩一,小川誠司,林泰秀
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] Genome-wide scanning of pediatric acute myeloied leukemia using SNP-genotyping microarrays (2010)
  • Author(s): Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Ohkubo J, Uchisaka N, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] Mutations of IDH1 and IDH2 in pediatric acute myeloid leukemia (2010)
  • Author(s): Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Ohkubo J, Uchisaka N, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] 胸膜肺芽腫における網羅的ゲノム解析 (2010)
  • Author(s): 大久保淳,滝田順子,大木健太郎,西村力,内坂直樹,安達正時,真田昌,加藤啓輔,林泰秀,五十嵐隆,小川誠司
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 小児固形腫瘍におけるALK遺伝子の関与 (2010)
  • Author(s): 滝田順子,西村力,大木健太郎,樋渡光輝,大久保淳,内坂直紀,真田昌,大喜多肇,藤本純一郎,金兼弘和,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 小児T細胞性造血器腫瘍におけるLEF1遺伝子の異常 (2010)
  • Author(s): 朴明子,加藤元博,清河信敬,滝田順子,小川誠司,林泰秀
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 小児固形腫瘍におけるALK阻害剤を用いた抗腫瘍効果の検討 (2010)
  • Author(s): 樋渡光輝,滝田順子,大久保淳,西村力,大木健太郎,内坂直樹,安達正時,真田昌,加藤啓輔,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 難治性小児固形腫瘍におけるALK変異と臨床応用 (2010)
  • Author(s): 西村力,滝田順子,真田昌,大久保淳,大木健太郎,加藤元博,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第7回北関東小児がんセミナー
  • Place of Presentation: 高崎
  • Year and Date: 2010-05-15
• [Presentation] 小児白血病の発症,進展の分子遺伝学 (2010)
  • Author(s): 林泰秀
  • Organizer: 113回日本小児科学会学術集会(シンポジウム)
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-25
• [Presentation] 小児T細胞性急性リンパ性白血病における網羅的ゲノム解析 (2010)
  • Author(s): 朴明子,加藤元博,清河信敬,滝田順子,真田昌,小川誠司,林泰秀
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-24
• [Presentation] 若年性骨髄単球性白血病におけるCBL遺伝子の解析 (2010)
  • Author(s): 柴徳生,加藤元博,朴明子,真田昌,金澤崇,黒澤秀光,伊藤悦朗,荒川浩一,小川誠司,林泰秀
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-24
• [Presentation] Ewing/PNET familyにおけるALK遺伝子の解析 (2010)
  • Author(s): 滝田順子,西村力,大木健太郎,金兼弘和,大喜多肇,藤本純一郎,菊地陽,林泰秀,五十嵐隆,小川誠司
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-24
• [Presentation] 神経芽腫における部分欠損型ALKの活性化 (2010)
  • Author(s): 大木健太郎,滝田順子,西村力,加藤元博,陳玉彦,真田昌,菊地陽,林泰秀,五十嵐隆,小川誠司
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-24
• [Presentation] 小児固形腫瘍におけるALK阻害剤の効果に関する検討 (2010)
  • Author(s): 大久保淳,滝田順子,西村力,大木健太郎,加藤元博,真田昌,加藤啓輔,菊地陽,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第113回日本小児科学会学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-24
• [Presentation] ALK gene aberrations in pediatric solid tumors. (2010)
  • Author(s): Takita J, Nishimura R, Sanada M, Ohki K, Motohiro K, Chen YY, Kanegane H, Okita H, Fujimoto J, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-04-15
• [Presentation] High resolution copy number analysis of Ewing sarcoma family of tumors using high-density SNP-genotyping microarrays (2010)
  • Author(s): Nishimura R, Takita J, Ohki K, Kato M, Chen YY, Sanada M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: The 6th Congress of Asian Society for Pediatric Research & 51st Annual Meeting of Taiwan Pediatric Association
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2010-04-15
• [Presentation] 高密度SNPアレイを用いた小児T細胞性腫瘍における網羅的ゲノム解析 (2010)
  • Author(s): 朴明子,加藤元博,清河信敬,滝田順子,真田昌,小川誠司,林泰秀
  • Organizer: 第8回日本臨床腫瘍学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-19
• [Presentation] (2009)
  • Author(s): 加藤元博,真田昌,加藤格,佐藤康晴,滝田順子,竹内賢吾,丹羽明,陳玉彦,中崎久美,野本順子,川幡亮一郎,朝倉義崇,赤塚美樹,林泰秀,森啓,五十嵐隆,黒川峰夫,千葉滋,森茂郎,石川雄一,岡本康司,飛内賢正,中釜斉,中畑龍俊,吉野正,小林幸夫,小川誠司
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-12
• [Presentation] 小児固形腫瘍におけるALK遺伝子の解析 (2009)
  • Author(s): 滝田順子,西村力,大木健太郎,陳玉彦,加藤元博,真田昌,金兼弘和,大喜多肇,藤本純一郎,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-12
• [Presentation] 小児固形腫瘍におけるALK遺伝子の解析 (2009)
  • Author(s): 滝田順子,大木健太郎,西村力,陳玉彦,加藤元博,金兼弘和,大喜多肇,藤本純一郎,真田昌,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第54回日本人類遺伝学会第54回大会
  • Place of Presentation: 東京
  • Year and Date: 20090923-26
• [Presentation] 各種腫瘍における高密度SNPアレイを用いた網羅的ゲノムプロファイリング (2009)
  • Author(s): 松原亜以子,加藤元博,真田昌,滝田順子,千葉滋,林泰秀,小俣政男,小林幸夫,渡邉俊樹,石川雄一,吉野正,小川誠司, Koeffler HP, Bratram CR.
  • Organizer: 第54回日本人類遺伝学会,第54回大会
  • Place of Presentation: 東京
  • Year and Date: 20090923-26
• [Presentation] Aberrations of genes regulating NFκB pathway in B-cell malignant lymphoma (2009)
  • Author(s): Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Kawahata R, Niwa A, Chen y, Nakazaki K, Nomoto J, Asakura Y, Akatsuka Y, Hayashi Y, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S
  • Organizer: 第51回American Society of Hematology
  • Place of Presentation: New Orleans
  • Year and Date: 2009-12-08
• [Presentation] Down症候群に伴うtransient abnormal myelopoiesis(TAM)の予後因子についての検討 (2009)
  • Author(s): 朴明子,佐野弘純,小笠原水穂,嶋田明,外松学,井田孔明,林泰秀
  • Organizer: 第51回日本小児血液学会、第25回日本小児がん学会
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-29
• [Presentation] NUP98遺伝子再構成を有する小児造血器腫瘍に同定された遺伝子変異とその臨床的意義 (2009)
  • Author(s): 竹谷健,滝智彦,福田誠司,山口清次,林泰秀
  • Organizer: 第51回日本小児血液学会、第25回日本小児がん学会
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-29
• [Presentation] T細胞性急性リンパ性白血病におけるPTENとP13K-AKT経路の遺伝子解析 (2009)
  • Author(s): 朴明子,滝智彦,小田慈,八木啓子,小林良二,鈴木信寛,原純一,堀部敬三,林泰秀
  • Organizer: 第51回日本小児血液学会、第25回日本小児がん学会
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-27
• [Presentation] 神経芽腫における短縮型ALKによる活性化 (2009)
  • Author(s): 加藤元博,滝田順子,陳玉彦,大木健太郎,西村力,真田昌,井田孔明,菊地陽,小川誠司,林泰秀,五十嵐隆
  • Organizer: 第51回日本小児血液学会、第25回日本小児がん学会
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-27
• [Presentation] 固形腫瘍におけるALK遺伝子の解析 (2009)
  • Author(s): 大木健太郎,滝田順子,陳玉彦,西村力,加藤元博,金兼弘和,大喜多肇,藤本純一郎,真田昌,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第51回日本小児血液学会、第25回日本小児がん学会
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-27
• [Presentation] 高密度SNPアレイを用いたユーイング肉腫における網羅的ゲノム解析 (2009)
  • Author(s): 西村力,滝田順子,大木健太郎,加藤元博,陳玉彦,真田昌,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第51回日本小児血液学会、第25回日本小児がん学会
  • Place of Presentation: 千葉
  • Year and Date: 2009-11-27
• [Presentation] 小児急性骨髄性白血病におけるWT1遺伝子変異と臨床像 (2009)
  • Author(s): 佐野弘純,久保田知里,朴明子,嶋田明,外松学,滝智彦,田渕健,多和昭雄,堀部敬三,土田昌宏,花田良二,月本一郎,林泰秀
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-25
• [Presentation] 小児B細胞性リンパ腫のマイクロアレイを用いたmolecular karyotypingと網羅的発現遺伝子解析 (2009)
  • Author(s): 清河信敬,恩田恵子,飯島一智,長谷川大輔,加藤元博,大喜多肇,齋藤正博,森鉄也,真部淳,康勝好,小原明,林泰秀,花田良二,土田昌宏,中川温子,小川誠司,藤本純一郎
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-25
• [Presentation] A Japanese pedigree with RUNX1 mutation resulting in FPD/AML (2009)
  • Author(s): Hasegawa D, Ogawa C, Hirabayashi S, Park MJ, Hayashi Y, Manabe A, Hosoya R.
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] Clinical sighificance of somatic mutations in hematological malignancies with NUP98-fusion genes (2009)
  • Author(s): Taketani T, Taki T, Fukada S, Yamaguchi S, Hayashi Y
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] Molecular allelo-karyotype of adult acute lymphoblastic leukemia(ALL) and pediatric ALL (2009)
  • Author(s): Okubo J, Kato M, Takita J, Sanada M, Ohki K, Nishimura R, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-24
• [Presentation] Frequent inactivation of A20 throuh gene mutation in B-cell lymphomas (2009)
  • Author(s): Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-23
• [Presentation] Genome-wide analysis of pediatric T-cell acute lymphoblastic leukemia (2009)
  • Author(s): Park MJ, Kato M, Kiyokawa N, Sanada M, Takita J, Ogawa S, Hayashi Y.
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-23
• [Presentation] 各種腫瘍における高密度SNPアレイを用いた網羅的ゲノムプロファイリング (2009)
  • Author(s): 松原亜以子,加藤元博,真田昌,滝田順子,千葉滋,林泰秀,小俣政男,小林幸夫,渡邉俊樹,石川雄一,吉野正,小川誠司
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 小児固形腫瘍におけるALK遺伝子の増幅と変異 (2009)
  • Author(s): 滝田順子,大木健太郎,西村力,加藤元博,陳玉彦,真田昌,金兼弘和,大喜多肇,藤本純一郎,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 小児T細胞型急性リンパ性白血病における網羅的ゲノム解析 (2009)
  • Author(s): 朴明子,加藤元博,清河信敬,真田昌,滝田順子,小川誠司,林泰秀
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] 小児固形腫瘍におけるALK阻害剤の感受性 (2009)
  • Author(s): 本村あい,滝田順子,大木健太郎,西村力,加藤元博,陳玉彦,真田昌,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] ユーイング肉腫における高密度SNPアレイによる網羅的遺伝子解析 (2009)
  • Author(s): 西村力,滝田順子,大木健太郎,加藤元博,陳玉彦,真田昌,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 神経芽細胞腫のALK遺伝子異常によるALKキナーゼ活性の異常増幅 (2009)
  • Author(s): 大木健太郎,滝田順子,西村力,加藤元博,陳玉彦,真田昌,菊地陽,五十嵐隆,林泰秀,小川誠司
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 神経芽腫におけるALK遺伝子の解析 (2009)
  • Author(s): 滝田順子,陳玉彦,加藤元博,大平美紀,菊地陽,中川原章,野間博行,林泰秀,五十嵐隆,小川誠司
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2009-04-18
• [Presentation] 小児がんにおける網羅的なLoss of heterozygosity(LOH)解析 (2009)
  • Author(s): 加藤元博,滝田順子,陳玉彦,真田昌,大木健太郎,滝智彦,菊地陽,林泰秀,小川誠司,五十嵐隆
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2009-04-18
• [Presentation] 超高密度オリゴヌクレオチドアレイを用いた小児横紋筋肉腫における網羅的ゲノム解析 (2009)
  • Author(s): 大木健太郎,滝田順子,加藤元博,陳玉彦,真田昌,林泰秀,五十嵐隆,小川誠司
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 2009-04-17
• [Remarks]
  • URL: http://www.gcmc.pref.gunma.jp/