2011 Fiscal Year Final Research Report
Development of bone regeneration methods for large bone defect using bone marrow derived mesenchymal stem cells.
| Project/Area Number |
21390418
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SOTOME Shinichi 東京医科歯科大学, 医歯学総合研究科, 寄付講座教員 (20401391)
ENOMOTO Mitsuhiro 東京医科歯科大学, 医歯学総合研究科, 寄付講座教員 (90451971)
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| Co-Investigator(Renkei-kenkyūsha) |
AE Keisuke 東京医科歯科大学, 医学部, 非常勤講師 (20376726)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨再生 / 骨髄間葉系幹細胞 / 分化能 / 骨形成能 / 大型骨欠損 |
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| Research Abstract |
Bone marrow mesenchymal stem cells(MSCs) have pluripotent differentiation capability and are expected to be used for regenerative medicine. However, the differentiation capability decreases with their prolonged proliferation. Moreover, our previous studies showed that the such cells had not only less bone formation capability but also suppressed bone formation. In this study, we focused on EPHA5 as the suppressor candidate from microarray and co-culture study.
We achieved 5 cm long bone regeneration using MSCs in a monkey femur bone defect model. The regenerated bone proved its bone union capability that is one of the impossible characteristics of natural bone.
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[Journal Article] Repair of large osteochondral defects in rabbits using porous hydroxyapatite/collagen(HAp/Col) and fibroblast growth factor-2(FGF-2)2010
Author(s)
Maehara H, Sotome S, Yoshii T, Torigoe I, Kawasaki Y, Sugata Y, Yuasa M, Hirano M, Mochizuki N, Kikuchi M, Shinomiya K, Okawa A
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Journal Title
Journal of Orthopaedic Research
Volume: 28(5)
Pages: 677-686
Peer Reviewed
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[Journal Article] Effects of gamma-ray irradiation on mechanical properties, osteoconductivity, and absorption of porous hydroxyapatite/collagen2010
Author(s)
Kawasaki Y, Sotome S, Yoshii T, Torigoe I, Maehara H, Sugata Y, Hirano M, Mochizuki N, Shinomiya K, Okawa A
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Journal Title
Journal of Biomedical and Materials Research B Applied Biomaterials
Volume: 92(1)
Pages: 161-167
Peer Reviewed
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[Journal Article] Bone regeneration with autologous plasma, bone marrow stromal cells, and porous beta-tricalcium phosphate in nonhuman primates2009
Author(s)
Torigoe I, Sotome S, Tsuchiya A, Yoshii T, Maehara H, Sugata Y, Ichinose S, Shinomiya K, Okawa A
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Journal Title
Tissue Engineering Part A
Volume: 15(7)
Pages: 1489-1499
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[Journal Article] Hybrid Grafting using Bone Marrow Aspirate combined with Porous beta-Tricalcium Phosphate and Trephine Bone for Lumbar Posterolateral Spinal Fusion : A Prospective, Comparative Study-Versus Local Bone Grafting
Author(s)
Yamada T, Yoshii T, Sotome S, Yuasa M, Kato T, Arai Y, Kawabata S, Tomizawa S, Sakaki K, Hirai T, Shinomiya K, Okawa A
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Journal Title
Peer Reviewed
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