2011 Fiscal Year Final Research Report
Effects of proteases on differentiation and maturation of oligodendrocytes
| Project/Area Number |
21500322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
BANDO Yoshio 旭川医科大学, 医学部, 講師 (20344575)
MURAKAMI Koichi 旭川医科大学, 医学部, 助教 (90400085)
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| Project Period (FY) |
2009 – 2011
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| Keywords | オリゴデンドロサイト / プロテアーゼ / KLK6 / 発達 / ミエリン / 脱髄 |
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| Research Abstract |
KLK6 is a serine protease specifically expressed in oligodendrocytes. The function of the protease on the maturation of oligodendrocyte has been undetermined. We analyzed KLK6 gene knockout (KLK6-KO) mice and found that the development of oligodendrocytes was temporally delayed. We also found that the expression of myelin basic protein was smaller in KLK6-KO mice than that of wild-type mice. These results indicate that KLK6 plays a role in the development of oligodendrocytes.
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