2011 Fiscal Year Final Research Report
Structural and morphology changes in the disease model after amnion stem cell transplantation
| Project/Area Number |
21590212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Toyama |
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Principal Investigator |
YOSHIDA Toshiko 富山大学, 大学院・医学薬学研究部(医学), 准教授 (00171421)
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| Co-Investigator(Kenkyū-buntansha) |
NIKAIDO Toshio 富山大学, 大学院・医学薬学研究部(医学), 教授 (50180568)
OKABE Motonori 富山大学, 大学院・医学薬学研究部(医学), 助教 (60283066)
KOIKE Chika 富山大学, 大学院・医学薬学研究部(医学), 助教 (10523889)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ヒト羊膜細胞 / 疾患モデル / 分化誘導 / 糖尿病モデル / 脊髄損傷モデル / 骨欠損モデル / 骨分化 |
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| Research Abstract |
The stem cells contained in an amnion epithelium cells and mesenchymal cells in the amnion membrane were purified. The stem cells were transported in to disease model.
In the diabetes model, blood glucose level became low temporarily and survival benefit was seen. In the cord injury model, in spite of having transplanted the mesenchymal cells one week after damage, the motor function was recovered significantly. In the bone deficit model, in spite of xenograft, rejection hardly started but the bone tissue has been reproducing.
The amnion stem cells were effective as a cell material of regeneration medicine.
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Research Products
(47 results)
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[Journal Article] Traditional Japanese formula kigikenchuto accelerates healing of pressure-loading skin ulcer in rats.2011
Author(s)
Kimura M., Shibahara N., Hikiami H., Yoshida T., Jo M., Kaneko M., Mogami T., Fujimoto M., Goto H., and Shimada Y.
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Journal Title
Evid Based Complement Altemat Med
Volume: 2011
Pages: 592791, 9
Peer Reviewed
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[Journal Article] Establishment of Immortalized Human Amniotic Mesenchymal Stem Cells2011
Author(s)
Teng Z., Yoshida T., Okabe M., Toda A., Higuchi 0., Nogami M., Yoneda N., Zhou K., Kyo S., Kiyono T., and Nikaido T.
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Journal Title
Cell Transplant
Volume: (in pres)
Peer Reviewed
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[Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour2010
Author(s)
Ito M., _Nakasima A., Hidaka T., Okabe M., Bac ND., Ina S., Yoneda S., Shiozaki A., Sumi S., Tuneyama K., Nikaido T., Saito S.
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Journal Title
J Reprod Immunol
Volume: 84
Pages: 75-85
Peer Reviewed
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[Presentation] 新規ヒト乾燥羊膜(Hyper-Dry羊膜)の臨床における有用性2011
Author(s)
岡部素典,吉田淑子,小池千加,林央周,藤坂実千郎,将積日出夫,新井直也,津野宏彰,北川清隆,遠藤俊郎,渡邉行雄,野口誠,林篤志,齋藤滋,二階堂敏雄
Organizer
第10回日本再生医療学会総会
Place of Presentation
東京
Year and Date
20110301-02
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[Presentation] ヒト羊膜由来細胞2010
Author(s)
岡部素典,吉田淑子,小池千加,津野宏彰,二階堂敏雄
Organizer
第115回日本解剖学会総会・全国学術集会
Place of Presentation
盛岡
Year and Date
20100328-30
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[Presentation] マウス羊膜幹細胞の分化能2009
Author(s)
吉田淑子, Teng Zan,周凱旋,岡部素典,小池千加,米田徳子,野上真紀子,樋口収,二階堂敏雄
Organizer
第8回日本再生医療学会総会
Place of Presentation
東京
Year and Date
20090305-06
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