Adverse neurodevelopment in infancy associated with maternal smoking during pregnancy and genetic polymorphisms : exploiting gene-environmental interaction

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590678
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Hokkaido University
• Principal Investigator: SASAKI Seiko 北海道大学, 大学院・医学研究科, 助教 (30448831)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Sonomi 札幌医科大学, 保健医療学部, 講師 (70325877)
• Co-Investigator(Renkei-kenkyūsha): KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
• Project Period (FY): 2009 – 2011
• Keywords: 母子保健

Research Abstract

Genetic susceptibility to tobacco smoke might have relation to adverse birth outcomes. To estimate the effects of maternal smoking during pregnancy and genetic polymorphisms on infant neurodevelopment, we conducted a prospective birth cohort study of women who delivered singleton live births. Multiple linear regression models were used to estimate the association maternal smoking and certain polymorphisms with cognitive deficits at 6, 18 and 42 months of age. There was no correlation between any of the genotypes and adverse effects.

Research Products

• [Journal Article] Effects of maternal 5,10-methylenetetra hydrofolatereductase C677T and A1298C polymorphisms and tobacco smoking on infant birth weight in a Japanese population (2012)
  • Author(s): Yila TA, Sasaki S, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, EndoG, Sengoku K, Kishi R
  • Journal Title: J Epidemiology Volume: 22(2) Pages: 91-102
  • Peer Reviewed
• [Journal Article] Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants (2011)
  • Author(s): Okada E, Sasaki S, Saijo Y, Washino N, Miyashita C, Kobayashi S, Konishi K, Ito YM, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R
  • Journal Title: Environ Res Volume: 112(1) Pages: 118-125
  • Peer Reviewed
• [Journal Article] Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, Japan (2011)
  • Author(s): Todaka T, Hirakawa H, Kajiwara J, Onozuka D, Sasaki S, Miyashita C, Yoshioka E, Yuasa M, Kishi R, Iida T, Uchi H, Furue M
  • Journal Title: Chemosphere Volume: 85(11) Pages: 1694-1700
  • Peer Reviewed
• [Journal Article] Cohort Profile : The Hokkaido Study on Environment and Children's Health in Japan (2011)
  • Author(s): Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F, Saijo Y, Kurahashi N, Tamaki J, Endo T, Sengoku K, Nonomura K, Minakami H
  • Journal Title: Int J Epidemiol Volume: 40(3) Pages: 611-618
  • Peer Reviewed
• [Journal Article] Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy (2011)
  • Author(s): Miyashita C, Sasaki S, SaijoY, Washino N, Okada E, Kobayashi S, Konishi K, Kajiwara J, Todaka T, Kishi R
  • Journal Title: Environ Res Volume: 111(4) Pages: 551-558
  • Peer Reviewed
• [Journal Article] 北海道の妊婦の全血中POPs系農薬の濃度-「環境と子どもの健康に関する北海道研究」 (2011)
  • Author(s): 金澤文子, 宮下ちひろ, 岡田恵美子, 小林澄貴, 鷲野孝揚, 湯浅資之, 佐木成子, 吉岡英治, 水谷太, 苣木洋一, 岸玲子.
  • Journal Title: 日本衛生学雑誌 Volume: 66(1) Pages: 95-107
  • Peer Reviewed
• [Journal Article] Furue M. Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milk (2010)
  • Author(s): Todaka T, Hirakawa H, Kajiwara J, Hori T, Tobiishi K, Yasutake D, Onozuka D, SasakiS, Miyashita C, Yoshioka E, Yuasa M, Kishi R, Iida T
  • Journal Title: Chemosphere Volume: 78(2) Pages: 185-192
  • Peer Reviewed
• [Journal Article] 生後6ヶ月児に対するベイリー乳幼児発達検査-第2版による発達評価とその有用性 (2010)
  • Author(s): 中島そのみ, 仙石泰仁, 中村裕二, 加藤静恵, 岸玲子
  • Journal Title: 作業療法 Volume: 29(3) Pages: 309-316
  • Peer Reviewed
• [Journal Article] 出生コホート研究の現状と今後の課題-日本で前向き研究を実施してきた経験から- (2010)
  • Author(s): 岸玲子, 佐木成子
  • Journal Title: 保健医療科学 Volume: 59(4) Pages: 366-371
  • Peer Reviewed
• [Journal Article] 環境化学物質の次世代影響に関するわが国における研究事例-北海道スタディの概要とこれまでの成果. (2010)
  • Author(s): 岸玲子, 佐木成子
  • Journal Title: 医学のあゆみ Volume: 235(11) Pages: 1117-1121
• [Journal Article] 遺伝的ハイリスク群への対応を-喫煙と遺伝的感受性の複合効果による出生体重低下の知見から (2009)
  • Author(s): 佐木成子, 岸玲子
  • Journal Title: 科学 Volume: 79(9) Pages: 978-981
• [Journal Article] 環境と子どもの健康に関するコーホート研究について-子どもの発達評価とその課題- (2009)
  • Author(s): 中島そのみ, 岸玲子
  • Journal Title: 日本衛生学雑誌 Volume: 64(4) Pages: 765-773
  • Peer Reviewed
• [Journal Article] 遺伝的感受性素因の重要性-母の喫煙が子どもの胎内発育に及ぼす影響- (2009)
  • Author(s): 佐木成子, 岸玲子
  • Journal Title: 日本衛生学雑誌 Volume: 64(4) Pages: 759-764
  • Peer Reviewed
• [Journal Article] Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight (2009)
  • Author(s): Konishi K, Sasaki S, Kato S, Ban S, Washino N, Kajiwara J, Todaka T, Hiarkawa H, Hori T, Yasutake D, Kishi R
  • Journal Title: Environ Res Volume: 109(7) Pages: 906-913
  • Peer Reviewed
• [Journal Article] Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. (2009)
  • Author(s): Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R.
  • Journal Title: Environ Health Persp Volume: 117(4) Pages: 660-667
  • Peer Reviewed
• [Journal Article] Blood persistent organochlorine pesticides of pregnant women relating to their characteristics in the Hokkaido Study on environment and children's health
  • Author(s): Kanazawa A, Miyashita C, Okada E, Kobayashi S, WashinoN, Sasaki S, Yoshioka E, Mizutani F, Chisaki Y, Saijo Y, Kishi R
  • Journal Title: Sci Total Environ Volume: (In press)
  • Peer Reviewed
• [Presentation] 妊婦血と毛髪の環境化学物質に関連する要因-環境と子どもの健康北海道スタディ- (2012)
  • Author(s): 宮下ちひろ,佐木成子,岡田恵美子,小林澄貴,蜂谷紀之,岩崎雄介,中澤裕之,梶原淳睦,戸高尊,岸玲子
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学吉田キャンパス, 京都
  • Year and Date: 2012-03-25
• [Presentation] ヒトの出産前後における血液DEHP代謝物濃度の解析 (2012)
  • Author(s): 田川雅大,内藤久雄,林由美,川野愛子佐木成子,荒木敦子,小林澄貴,岸玲子
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学吉田キャンパス, 京都
  • Year and Date: 2012-03-25
• [Presentation] Effects of prenatal environmental tobacco smoke exposure on infant birth size (2011)
  • Author(s): Braimoh TS, Sasaki S, Yila TA, Baba T, Miyashita C, Okada E, Kashino I, Ito K, Kobayashi S, Yoshioka E, Kishi R
  • Organizer: The American Public Health Association (APHA) 139th Annual Meeting and Exposition
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-10-29
• [Presentation] The effects of PFOS and PROA in maternal serum on maternal and infant thyroid hormones (2011)
  • Author(s): Itoh S, Kato S, Yuasa M, Sasaki S, Yoshioka E, Kashino I, Okada E, Miyashita C, Kishi R
  • Organizer: ISEE2011
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-09-14
• [Presentation] 生体試料中ビスフェノールA分析の検討 (2011)
  • Author(s): 山本潤,羽山真介,佐藤修之,松村徹,岸玲子,佐木成子,宮下ちひろ
  • Organizer: 日本環境化学会第20回環境化学討論会
  • Place of Presentation: 熊本県立大学, 熊本
  • Year and Date: 2011-07-17
• [Presentation] Effects of exposure to second-hand smoke during pregnancy on birth size (2011)
  • Author(s): Braimoh TS, Sasaki S, Yila TA, Baba T, Miyashita C, Okada E, Kashino I, Ito K, Kobayashi S, Yoshioka E, Kishi R
  • Organizer: Women's Health Conference
  • Place of Presentation: New York, USA
  • Year and Date: 2011-04-02
• [Presentation] 母体血中ダイオキシン類と6ヶ月・18ヶ月児の精神・運動発達への影響-環境と子どもの北海道スタディ(3)- (2011)
  • Author(s): 中島そのみ,佐木成子,加藤静恵,鵜野安希子,中村裕二,仙石泰仁,梶原淳睦,西條泰明,岸玲子
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 昭和大学旗の台キャンパス,東京
  • Year and Date: 2011-03-27
• [Presentation] 生後42ヶ月児における認知能と胎児期PCB・ダイオキシン類曝露との関連-環境と子どもの北海道スタディ(4)- (2011)
  • Author(s): 小西香苗,坂晋,佐木成子,鷲野考揚,吉岡英治,梶原淳睦,戸高尊,中島そのみ,岸玲子
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 昭和大学旗の台キャンパス,東京
  • Year and Date: 2011-03-27
• [Presentation] 妊婦葉酸値と先天異常リスクとの関連-環境と子どもの健康に関する北海道スタディ(1)- (2011)
  • Author(s): 伊藤久美子,佐木成子,Yila TA,馬場俊明,宮下ちひろ,樫野いく子,岡田恵美子,小林澄貴,吉岡英治,岸玲子
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 昭和大学旗の台キャンパス,東京
  • Year and Date: 2011-03-26
• [Presentation] 抗エストロゲン様作用PCBs曝露と出生体格との関連-環境と子どもの北海道スタディ(2)- (2011)
  • Author(s): 宮下ちひろ,佐木成子,岡田恵美子,小林澄貴,西條泰明,吉岡英治,馬場俊明,梶原淳睦,戸高尊,岸玲子
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 昭和大学旗の台キャンパス,東京
  • Year and Date: 2011-03-26
• [Presentation] AhRおよびAhRR遺伝子多型と母体血中ダイオキシン類濃度との関連-『環境と子どもの健康に関する北海道スタディ』 (2011)
  • Author(s): 小林澄貴,佐木成子,坂晋,宮下ちひろ,岡田恵美子,Limpar M,吉岡英治,梶原淳睦,戸高尊,岸玲子
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道立道民活動センター, 札幌
  • Year and Date: 2011-01-22
• [Presentation] Relationship between AhR gene polymorphisms and dioxin concentrations in maternal blood-Hokkaido Study on Environment and Children's Health- (2010)
  • Author(s): Sasaki S, Kobayashi S, Ban S, Yoshioka E, Miyashita C, OkadaE, Limpar M, Yila TA, Baba T, Braimoh TS, Kashino I, Otake Y, Kanazawa A, Yuasa M, Kajiwara J, Todaka T, Kishi R
  • Organizer: ISES-ISEE2010
  • Place of Presentation: Seoul, South Korea.
  • Year and Date: 2010-08-29
• [Presentation] Prenatal Exposure to Dioxins in Relation to Allergy and Infection in Infancy-Hokkaido Study on Environment and Children's Health- (2010)
  • Author(s): Miyashita C, Sasaki S, YoshiokaE, Yila TA, Baba T, Braimoh TS, Kashino I, Okada E, Kobayashi S, Otake Y, Limpar M, Kajiwara J, Todaka T, Kishi R.
  • Organizer: ISES-ISEE2010
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2010-08-29
• [Presentation] 妊婦の喫煙と血中ダイオキシン類濃度との関連-「環境と子どもの健康北海道スタディ」(3) (2010)
  • Author(s): 坂晋,佐木成子,小西香苗,吉岡英治,鷲野考揚,戸高尊,平川博仙,梶原淳睦,岸玲子
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター,仙台
  • Year and Date: 2010-05-11
• [Presentation] 難分解性有機塩素系農薬の妊婦への曝露状況-「環境と子どもの健康北海道スタディ」(4) (2010)
  • Author(s): 金澤文子,佐々木成子,鷲野孝揚,宮下ちひろ,岡田惠美子,小林澄貴,吉岡英治,水谷 太,苣木洋一,岸玲子
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター,仙台
  • Year and Date: 2010-05-11
• [Presentation] First Trimester Serum Folate Status of Japanese Women in Hokkaido-The Hokkaido Study on Environment and Children's Health (5) (2010)
  • Author(s): Yila TA, Sasaki S, Baba T, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Yoshioka E, Kishi R
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター,仙台
  • Year and Date: 2010-05-11
• [Presentation] Self-Reported Exposure to Environmental Tobacco Smoke and Plasma Cotinine during Pregnancy-The Hokkaido Study on Environment and Children's Health (6) (2010)
  • Author(s): Braimoh TS, Sasaki S, Yila TA, Baba T, Miyashita C, Okada E, Kashino I, Kobayashi S, Yoshioka E, Kishi R
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター,仙台
  • Year and Date: 2010-05-11
• [Presentation] 北海道スタディグループ.コホートプロファイル-「環境と子どもの健康北海道スタディ」(1) (2010)
  • Author(s): 岸玲子,佐木成子,吉岡英治,湯浅資之,佐田文宏,西條泰明,倉橋典絵,玉置淳子
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター,仙台
  • Year and Date: 2010-05-10
• [Presentation] 母体血中ダイオキシン類の異性体濃度と乳幼児期の感染症との関連-「環境と子どもの健康 北海道スタディ」(2) (2010)
  • Author(s): 宮下ちひろ,佐木成子,鷲野考揚,小西香苗,岡田恵美子,吉岡英治,湯浅資之,梶原淳睦,戸高尊,岸玲子
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター,仙台
  • Year and Date: 2010-05-10
• [Presentation] 北海道における有機塩素系農薬の妊婦への曝露状況 (2009)
  • Author(s): 金澤文子,佐々木成子,加藤静恵,鷲野孝揚,宮下ちひろ,岡田惠美子,小林澄貴,吉岡英治,岸玲子,水谷 太,苣木洋一
  • Organizer: 北海道公衆衛生学会
  • Place of Presentation: 北海道大学学術交流会館, 札幌
  • Year and Date: 2009-11-12
• [Presentation] Effects of maternal smoking and 5, 10-MTHFR C677T polymorphism on infant's birthweight -the impact of folic acid supplementation- (2009)
  • Author(s): Yila TA, Sasaki S, Braimoh TS, Kobayashi S, Limpar M, Yoshioka E, Kishi R
  • Organizer: 3rd Annual Conference on Genomics of Common Diseases
  • Place of Presentation: Cambridge, UK
  • Year and Date: 2009-09-24
• [Presentation] Effect of maternal serum perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) on maternal and newborn's thyroid hormone-Hokkaido Study on Environment and Children's Health- (2009)
  • Author(s): Yoshioka E, Yuasa M, Katoh S, Sasaki S, Washino N, Kanazawa A, Konishi K, Kishi R, Nakata A, Iwasaki Y, Ito R, Saito K, Nakazawa H
  • Organizer: 3rd WHO International Conference on CEH
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-06-08
• [Presentation] Prenatal Exposure to Dioxins in Relation to IgE level of Newborn and Allergic and Infectious Diseases of Infants-Hokkaido Study on Environment and Children's Health- (2009)
  • Author(s): Kishi R, Washino N, Miyashita C, Sasaki S, Yuasa M, Yoshioka E, Konishi K, Kajiwara J, Todaka T, Hirakawa H, Hori T
  • Organizer: 3rd WHO International Conference on CEH
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-06-08