Regulation of synaptic plasticity through inter-GPCR interplay

2010 Fiscal Year Final Research Report

• Project/Area Number: 21700359
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Juntendo University
• Principal Investigator: KAMIKUBO Yuji Juntendo University, 医学部, 助教 (80509670)
• Project Period (FY): 2009 – 2010
• Keywords: 分子 / 細胞神経科学

Research Abstract

In this project, I showed functional interaction of type-1 metabotropic glutamate receptor (mGluR1) with adenosine A1 receptor (A1R). A1R signaling modulates synaptic release and neuronal excitability in many neurons. mGluR1 is a key molecule for inducing long-term depression. I found co-localization of A1R and mGluR1 in the plasma membrane. A1R agonists attenuated mGluR1-signaling and abolished LTD of glutamate-evoked current in cultured Purkinje cells

Research Products

• [Presentation] 代謝型グルタミン酸受容体(mGluR1)とアデノシンA1受容体(A1R)相互作用による小脳LTDの制御 (2010)
  • Author(s): 上窪裕二
  • Organizer: Neuro2010(神経科学会・神経化学会・神経回路学会 合同大会)
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-04
• [Presentation] A1アデノシン受容体とmGluR1のシグナル・クロストークによる小脳LTDの制御 (2010)
  • Author(s): 上窪裕二
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-03-17
• [Presentation] Adenosine A1 receptor regulates mGluR1 signaling and LTD in cerebellar Purkinje cells (2009)
  • Author(s): Y.Kamikubo
  • Organizer: Neuroscience 2009 39th annual neuroscience meeting (Society for Neuroscience)
  • Place of Presentation: Chicago's McCormick Place (Chicago、 Ill)
  • Year and Date: 2009-10-19
• [Presentation] Bi-directional regulation of cerebellar synaptic plasticity through inter-GPCR interplay (2009)
  • Author(s): Y.Kamikubo
  • Organizer: International Congress of Physiological Sciences(IUPS2009)
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2009-07-28
• [Presentation] アデノシンA1受容体による代謝型グルタミン酸受容体と小脳長期抑圧の制御
  • Author(s): 上窪裕二
  • Organizer: 第84回日本薬理学会年会、誌上発表
• [Remarks] ホームページ等
• [Remarks] 所属Webサイト
  • URL: http://pharmacology.sakura.ne.jp/
• [Remarks] アウトリーチ活動情報
• [Remarks] 生理学若手研究者フォーラム・代表(2009年7月4日、順天堂大学)
  • URL: http://youngphys.tobiiro.jp/