2010 Fiscal Year Final Research Report
Reconstituted biosynthesis of hybrid type natural products
| Project/Area Number |
21710222
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Meiji University (2010)
The University of Tokyo (2009) |
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Principal Investigator |
KUSHIRO Tetsuo Meiji University, 農学部, 准教授 (80373299)
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| Project Period (FY) |
2009 – 2010
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| Keywords | メロテルペノイド / テルペン環化酵素 / 糸状菌 / 遺伝子クラスター / ピリピロペン |
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| Research Abstract |
Pyripyropene, produced by a fungus Aspergillus fumigatus, is a meroterpenoid that is expected to be developed as a cholesterol lowering drug. The entire biosynthetic gene cluster was discovered and the function of each enzyme in the pathway was analyzed using fungal expression system. A completely novel terpene cyclase that is predicted to comprise of transmembrane helices was discovered for the first time.
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