2010 Fiscal Year Final Research Report

Characterization of the skin fibroblast, and induction of the artificial wound epidermis aiming for limb regeneration in mice

Research Project

Project/Area Number	21770244
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Developmental biology
Research Institution	Aichi Gakuin University
Principal Investigator	ENDO Tetsuya Aichi Gakuin University, 教養部, 講師 (90399816)
Project Period (FY)	2009 – 2010
Keywords	四肢再生 / 器官再生
Research Abstract	To clarify if mammalians can be induced to regenerate their limbs like amphibians do, two things were examined in neonatal mice as below. 1) Do skin fibroblasts maintain pattern formation potency? 2) Can the amphibian-type wound epidermis be formed on the amputation stump? In the organ culture system, even in mice, the amputation surface was covered by thin epidermal sheet within a few days, and the morphology of the sheet was similar to the amphibian-type wound epidermis. Those results suggest that the early events of amphibian limb regeneration might be inducible in neonatal mice

(1 results)