2010 Fiscal Year Final Research Report

Characterization of intestinal barrier defect in metabolic syndrome and the ameliorative effect of food factors

Research Project

Project/Area Number	21780117
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Food science
Research Institution	Hiroshima University
Principal Investigator	SUZUKI Takuya Hiroshima University, 大学院・生物圏科学研究科, 講師 (30526695)
Project Period (FY)	2009 – 2010
Keywords	栄養科学
Research Abstract	Studies using animal and cell culture models were conducted to investigate the mechanism(s) underlying the intestinal barrier defects in metabolic syndrome. The barrier defect was induced in the small intestines of the diet-induced obese rats, which was associated with the decreases in the tight junction protein expression. The experiment using the cultured intestinal cells showed that the barrier defect was induced by excessive dietary lipid and subsequent bile juice secretion.

(3 results)