2010 Fiscal Year Final Research Report
SH3P2 is a novel regulator of cell motility.
| Project/Area Number |
21790081
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
TANIMURA Susumu Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (90343342)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞運動 / ERK-MAPキナーゼ / RSK / リン酸化 |
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| Research Abstract |
We have found that SH3P2, a novel negative regulator of cell motility binds to Myo1E, which dissociates from SH3P2 in an RSK1-mediated Ser^<202> phosphorylation-dependent manner and regulates the expression of CD44 and MMP-3/-9. These results suggest that SH3P2/Myo1E complex is an essential machinery that functions downstream of the ERK-MAP kinase pathway to modulate cell motility.
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Research Products
(13 results)
