2010 Fiscal Year Final Research Report
Development of Host Nanoparticle - Guest PET Tracer System for Supersensitive Molecular Imaging and Drug Discovery
| Project/Area Number |
21790125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ZHANG Zhouen The Institute of Physical and Chemical Research, 分子イメージング創薬化学研究チーム, 研究員 (00416207)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ホスト・ナノ粒子-ゲストPETプローブシステム / 超高感度イメージング / ドラックデリバリー(DDS) / がん / PET |
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| Research Abstract |
In order to enhance the sensitivity and reliability of PET imaging, we proposed a novel strategy of amplifying tumor molecular marker, and attempted to develop multifunctional "tumor-targeting host nanoparticle-guest PET tracer system". PAMAM dendrimer - cyclodextrin (PAMAM-CD) as host nanoparticle, and several C-11 labeled carborane derivatives as guest PET tracers was designed and prepared. Such kind of host nanoparticle-guest PET tracer system could be applied to the supersensitive imaging for cancer diagnosis and imaging-guided therapy.
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