2010 Fiscal Year Final Research Report
The elucidation of the mechanisms underlying chemotherapeutic agents-induced nephrotoxicity and its precautions.
| Project/Area Number |
21790242
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
YANO Takahisa Kyushu University, 大学病院, 技術職員 (90532846)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 化学療法剤 / 腎障害 / ネクローシス / アポトーシス |
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| Research Abstract |
Both the antifungal agent amphotericin B (AmB) and anti-MRSA drug vancomycin(VCM) caused the mitochondrial dysfunction leading to a concentration- and time-dependent cell injury in cultured renal LLC-PK1 cells. Moreover, ROS generation may play a key role in VCM-induced renal tubular cell apoptosis.
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