2010 Fiscal Year Final Research Report
Complement receptor 2 is expressed by neural progenitor cells and regulates adult hippocampal neurogenesis in mice
| Project/Area Number |
21790393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Juntendo University |
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Principal Investigator |
HASEGAWA Maiko Juntendo University, 医学部, 助教 (20516637)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 補体受容体 / 神経新生 / 神経幹細胞 |
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| Research Abstract |
Complement receptor 2 (CR2) is expressed by neural progenitor cells and inhibits differentiation to neural lineage. Adult neurogenesis was increased in the dentate gyrus of CR2 deficient mice, indicating that neurogenesis might be promoted by down-regulating CR2 signaling.
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