Mechanism of mycobacterial growth using host hyaluronan and novel antitubercular drug development targeting mycobacterial hyaluronidase.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790426
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bacteriology (including Mycology)
• Research Institution: Osaka City University
• Principal Investigator: NIKI Mamiko Osaka City University, 大学院・医学研究科, 助教 (20438229)
• Project Period (FY): 2009 – 2010
• Keywords: 結核ビアルロン酸抗結核薬

Research Abstract

We found that mycobacteria can grow utilizing hyaluronan (HA) as a carbon source. The expression of HA synthase in the was increased after infection of M. tuberculosis. We showed HAase inhibitor suppressed growth of mycobacteria in vivo.

Research Products

• [Journal Article] Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis. (2011)
  • Author(s): Yukitake H, Naito M, Sato K, Shoji M, Ohara N, Yoshimura M, Sakai E, Nakayama K.
  • Journal Title: Microb Immun 55(3) Pages: 141-153
  • Peer Reviewed
• [Journal Article] Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise. (2011)
  • Author(s): Usui T, Yoshikawa T, Orita K, Ueda SY, Katsura Y, Fujimoto S, Yoshimura M.
  • Journal Title: Eur J Appl Physiol
  • Peer Reviewed
• [Journal Article] Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis. (2010)
  • Author(s): Kondo Y, Ohara N, Sato K, Yoshimura M, Yukitake H, Naito M, Fujiwara T, Nakayama K.
  • Journal Title: Infect Immun. 78(6) Pages: 2846-2856
  • Peer Reviewed
• [Journal Article] Mycobacteria exploit host hyaluronan for efficient extracellular replication. (2009)
  • Author(s): Hirayama Y, Yoshimura M, Ozeki Y, Sugawara I, Udagawa T, Mizuno S, Itano N, Kimata K, Tamaru A, Ogura H, Kobayashi K, Matsumoto S.
  • Journal Title: PLos Pathog. 5(10) Pages: e1000643
  • Peer Reviewed
• [Journal Article] Hydrogen sulfide production from cysteine and homocysteine by periodontal and oral bacteria. (2009)
  • Author(s): Yoshida A, Yoshimura M, Ohara N, Yoshimura S, Nagashima S, Takehara T, Nakayama K.
  • Journal Title: J.Periodontol. 80(11) Pages: 1845-1851
  • Peer Reviewed
• [Journal Article] Mycobacterium avium complex organisms predominantly colonize in the bathtub inlets of patients'bathrooms. (2009)
  • Author(s): Nishiuchi Y, Tamura A, Kitada S, Taguri T, Matsumoto S. Tateishi Y, Yoshimura M, Ozeki Y, Matsumura N, Ogura H, Maekura R.
  • Journal Title: Jpn J Infect Dis. 62(3) Pages: 182-186
  • Peer Reviewed
• [Journal Article] Virulence of Mycobacterium avium complex strains isolated from immunocompetent patients. (2009)
  • Author(s): Tateishi Y, Hirayama Y, Ozeki Y, Nishiuchi Y, Yoshimura M, Kang J, Shibata A, Hirata K, Kitada S, Maekura R, Ogura H, Kobayashi K, Matsumoto S.
  • Journal Title: Microb Pathog. 46(1) Pages: 6-12
  • Peer Reviewed