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2011 Fiscal Year Final Research Report

Screening for a new meningococcal pathogenic factor by STM

Research Project

  • PDF
Project/Area Number 21790435
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

TAKAHASHI Hideyuki  国立感染症研究所, 細菌第一部, 主任研究官 (60321866)

Project Period (FY) 2009 – 2011
Keywords感染症 / 微生物
Research Abstract

I constructed a transposon-inserted meningococcal mutant library by STM and screened adhesion or invasion-defective mutants to human brain microvasocular endothelial cells. By the 5th steps of screening, 31 mutants were finally selected.

  • Research Products

    (7 results)

All 2012 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Book (2 results)

  • [Journal Article] Meningococcal internalization into human endothelial and epithelial cell-s is triggered by the influx of extracellular L-glutamate via GltT L-glutamate ABC transporter in Neisseria meningitidis2011

    • Author(s)
      H. Takahashi, K. S. Kim and H. Watanabe
    • Journal Title

      Infection and Immunity

      Volume: 79 Pages: 380-392

    • DOI

      doi:10.1128/IAI.00497-10

    • Peer Reviewed
  • [Journal Article] Immunomoduatory effects of Yerisinia pestis Lipopolysaccharides on human Macrophages2010

    • Author(s)
      M. Matsuura, H. Takahashi, H. Watanabe and K. Kawahara
    • Journal Title

      Clinical and Vaccine Immunology

      Volume: 17 Pages: 49-55

    • DOI

      doi:10.1128/CVI.00336-09

    • Peer Reviewed
  • [Presentation] 髄膜炎菌の線毛のマイナータンパクPilVの宿主細胞感染における遺伝学的及び物理化学的手法を用いた機能解析2012

    • Author(s)
      高橋英之、大西真
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
  • [Presentation] 国内分離された髄膜炎菌株の分子役学的解析とそれらを用いたNeisseria meningitidisの病原因子の解析2009

    • Author(s)
      高橋英之
    • Organizer
      第92回細菌学会関東支部会シンポジウム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2009-11-08
  • [Presentation] 細菌感染時の髄膜炎菌の一過的なグルタミン酸の取込みが宿主細胞への侵入に必須である2009

    • Author(s)
      高橋英之、渡邉治雄
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-24
  • [Book] 感染症辞典2012

    • Author(s)
      川端寛樹、高橋英之
    • Total Pages
      3-27
    • Publisher
      オーム社
  • [Book] 病原菌の今日的意味14.髄膜炎菌2011

    • Author(s)
      高橋英之、大西真
    • Publisher
      医薬ジャーナル社

URL: 

Published: 2013-07-31  

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