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2011 Fiscal Year Final Research Report

The involvement and mechanism of mGluR1 for neurodegeneration induced by prion protein

Research Project

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Project/Area Number 21790448
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionNagasaki University

Principal Investigator

MATSUBARA Takehiro  長崎大学, 大学院・医歯薬学総合研究科, 助教 (10513294)

Project Period (FY) 2009 – 2011
Keywordsプリオン
Research Abstract

We found out that PrP bound to mGluR1 and through this binding, PrP modulated the activation of mGluR1.

  • Research Products

    (5 results)

All 2011 2010 2009 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] Cellular prion protein regulates the function of metabotropic glutamate receptor type I, through the binding2011

    • Author(s)
      Takehiro Matsubara, Katsuya Satoh, Yasuhito Uezono, Noriyuki Nishida
    • Organizer
      プリオン研究会
    • Place of Presentation
      長野県軽井沢
    • Year and Date
      2011-07-10
  • [Presentation] Cellular prion protein regulates the intracellular Ca^<2+> signaling through it binding to metabotropic glutamate receptor type I, mGluR12010

    • Author(s)
      Takehiro Matsubara, Yasuhito Uezono, Noriyuki Nishida
    • Organizer
      日本分子生物学会・生化学会合同大会
    • Place of Presentation
      兵庫県神戸
    • Year and Date
      2010-12-07
  • [Presentation] Cellular prion protein binds to metabotropic glutamate receptor type I and regulates its function2009

    • Author(s)
      Takehiro Matsubara, Naohiro Yamaguchi, Yuka Sudo, Yasuhito Uezono, Noriyuki Nishida
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神奈川県横浜
    • Year and Date
      2009-12-09
  • [Presentation] 異常型プリオン蛋白質による神経細胞変性死におけるmGluR1の役割とプリオン蛋白質との相互作用2009

    • Author(s)
      Takehiro Matsubara, Naohiro Yamaguchi, Yuka Sudo, Suehiro Sakaguchi, Yuko Ando, Noriyuki Nishida, Yasuhito Uezono
    • Organizer
      日本薬理学会
    • Place of Presentation
      神奈川県横浜
    • Year and Date
      2009-03-16
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/mmi/cmb/

URL: 

Published: 2013-07-31  

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