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2011 Fiscal Year Final Research Report

The involvement and mechanism of mGluR1 for neurodegeneration induced by prion protein

Research Project

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Project/Area Number 21790448
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionNagasaki University

Principal Investigator

MATSUBARA Takehiro  長崎大学, 大学院・医歯薬学総合研究科, 助教 (10513294)

Project Period (FY) 2009 – 2011
Keywordsプリオン
Research Abstract

We found out that PrP bound to mGluR1 and through this binding, PrP modulated the activation of mGluR1.

Research Products

(5 results)

All 2011 2010 2009 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] Cellular prion protein regulates the function of metabotropic glutamate receptor type I, through the binding2011

    • Author(s)
      Takehiro Matsubara, Katsuya Satoh, Yasuhito Uezono, Noriyuki Nishida
    • Organizer
      プリオン研究会
    • Place of Presentation
      長野県軽井沢
    • Year and Date
      2011-07-10
  • [Presentation] Cellular prion protein regulates the intracellular Ca^<2+> signaling through it binding to metabotropic glutamate receptor type I, mGluR12010

    • Author(s)
      Takehiro Matsubara, Yasuhito Uezono, Noriyuki Nishida
    • Organizer
      日本分子生物学会・生化学会合同大会
    • Place of Presentation
      兵庫県神戸
    • Year and Date
      2010-12-07
  • [Presentation] Cellular prion protein binds to metabotropic glutamate receptor type I and regulates its function2009

    • Author(s)
      Takehiro Matsubara, Naohiro Yamaguchi, Yuka Sudo, Yasuhito Uezono, Noriyuki Nishida
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神奈川県横浜
    • Year and Date
      2009-12-09
  • [Presentation] 異常型プリオン蛋白質による神経細胞変性死におけるmGluR1の役割とプリオン蛋白質との相互作用2009

    • Author(s)
      Takehiro Matsubara, Naohiro Yamaguchi, Yuka Sudo, Suehiro Sakaguchi, Yuko Ando, Noriyuki Nishida, Yasuhito Uezono
    • Organizer
      日本薬理学会
    • Place of Presentation
      神奈川県横浜
    • Year and Date
      2009-03-16
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/mmi/cmb/

URL: 

Published: 2013-07-31  

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