The involvement and mechanism of mGluR1 for neurodegeneration induced by prion protein

• Project/Area Number: 21790448
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Virology
• Research Institution: Nagasaki University
• Principal Investigator: MATSUBARA Takehiro 長崎大学, 大学院・医歯薬学総合研究科, 助教 (10513294)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: プリオン / prion protein / mGluR1 / Ca^<2+> / Prion Protein

Research Abstract

We found out that PrP bound to mGluR1 and through this binding, PrP modulated the activation of mGluR1.

Research Products

• [Presentation] Cellular prion protein regulates the function of metabotropic glutamate receptor type I, through the binding (2011)
  • Author(s): Takehiro Matsubara, Katsuya Satoh, Yasuhito Uezono, Noriyuki Nishida
  • Organizer: プリオン研究会
  • Place of Presentation: 長野県軽井沢
  • Year and Date: 2011-07-10
• [Presentation] Cellular prion protein regulates the intracellular Ca^<2+> signaling through it binding to metabotropic glutamate receptor type I, mGluR1 (2010)
  • Author(s): Takehiro Matsubara, Yasuhito Uezono, Noriyuki Nishida
  • Organizer: 日本分子生物学会・生化学会合同大会
  • Place of Presentation: 兵庫県神戸
  • Year and Date: 2010-12-07
• [Presentation] Cellular prion protein regulates the intracellular Ca^<2+> signaling through its binding to metabotropic glutamate receptor type I, mGluR1. (2010)
  • Author(s): 松原岳大
  • Organizer: 日本分子生物学会・日本生化学会合同大会
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-12-07
• [Presentation] Cellular prion protein binds to metabotropic glutamate receptor type I and regulates its function (2009)
  • Author(s): Takehiro Matsubara, Naohiro Yamaguchi, Yuka Sudo, Yasuhito Uezono, Noriyuki Nishida
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神奈川県横浜
  • Year and Date: 2009-12-09
• [Presentation] Cellular prion protein binds to metabotropic glutamate receptor type I and regulates its function (2009)
  • Author(s): 松原岳大
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] 異常型プリオン蛋白質による神経細胞変性死におけるmGluR1の役割とプリオン蛋白質との相互作用 (2009)
  • Author(s): Takehiro Matsubara, Naohiro Yamaguchi, Yuka Sudo, Suehiro Sakaguchi, Yuko Ando, Noriyuki Nishida, Yasuhito Uezono
  • Organizer: 日本薬理学会
  • Place of Presentation: 神奈川県横浜
  • Year and Date: 2009-03-16
• [Remarks]
  • URL: http://www.med.nagasaki-u.ac.jp/mmi/cmb/