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2010 Fiscal Year Final Research Report

Effects of Japanese Kanpo on gastrointestinal motility disorders in inflammatory bowel disease.

Research Project

  • PDF
Project/Area Number 21790629
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNagoya City University

Principal Investigator

KITO Yoshihiko  Nagoya City University, 大学院・医学研究科, 助教 (60381787)

Project Period (FY) 2009 – 2010
Keywords東洋医学
Research Abstract

Hange-shashin-to (TJ-14) and Keishi-ka-shakuyaku-to (TJ-60) inhibited the generation of spontaneous contractions of circular muscles in the rat distal colon. The production of nitric oxide was partially involved in those inhibitory effects. TJ-14 also inhibited atropine-sensitive contractions induced by transmural nerve stimulation (TNS), suggesting that TJ-14 seems to be effective in severe diarrhea in ulcerative colitis or Crohn disease. On the other hand, TJ-60 showed weak inhibitory effect on atropine-sensitive contractions induced by TNS. Thus, TJ-60 may be effective in irritable bowel syndrome, which causes recurring diarrhea and/or constipation in association with abdominal pain.

  • Research Products

    (4 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.2010

    • Author(s)
      Y Kito, H Suzuki
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology 298

      Pages: G755-G763

    • Peer Reviewed
  • [Journal Article] Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus.2009

    • Author(s)
      Y Kito, KM Sanders, SM Ward,H Suzuki
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology 297

      Pages: G814-G824

    • Peer Reviewed
  • [Presentation] Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus2010

    • Author(s)
      鬼頭佳彦
    • Organizer
      第52回日本平滑筋学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-07-02
  • [Presentation] Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus2010

    • Author(s)
      鬼頭佳彦
    • Organizer
      第6回 国際ICCミーティング
    • Place of Presentation
      宮崎
    • Year and Date
      2010-02-08

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Published: 2012-02-13   Modified: 2016-04-21  

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