2010 Fiscal Year Final Research Report
Vascular Endothelial Cells and Vesicle Structure
| Project/Area Number |
21790704
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AMIYA Eisuke The University of Tokyo, 医学部付属病院, 助教 (80529090)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 循環器・高血圧 / 脂質 / シグナル伝達 |
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| Research Abstract |
The objective of this study was to investigate about the relation between endothelial vesicle structures and endothelial function. This study demonstrated that vesicle structures detected in endothelial cytoplasm were the platform which modify the endothelial function through redox signaling or in lipid raft dependent manner. In addition, microparticle, extracellular vesicle structure which was derived from endothelial cell, was suggested to be also related with intracellular vesicle structure and have characteristics of proatherogenic properties.
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