2010 Fiscal Year Final Research Report
Effects of iron-overload on normal hematopoiesis and disease progression of hamatological malignancies
| Project/Area Number |
21790914
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
TANAKA Hirokazu Osaka University, 医学系研究科, 助教 (40360846)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 過剰鉄 / 造血幹細胞 / ストローマ細胞 / 活性酸素種 / 造血器腫瘍 |
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| Research Abstract |
In this study, we conducted the analyses regarding how does excessive "free"iron affect the growth and differentiation of hematopoietic cells as well as the characteristic of hematopoietic stromal cells.In addition, we investigated the effects of iron overload on the proliferation of MDS clones and the pathological transformation of MDS. As a result, excessive iron impairs hematopoiesis through direct effects on hematopoietic cells and indirect effects mediated by stromal cells. Furthermore, iron overload may induce the selective proliferation of MDS clones during the deterioration of normal hematopoiesis and may be involved in the leukemic transformation. These results are significant to reveal the mechanism and treatment of various hematopoietic disorders in terms of iron-kinetics.
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[Journal Article] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF1.2010
Author(s)
Tokunaga M, Ezoe S, Tanaka H, Satoh Y, Fukushima K, Matsui K, Shibata M, Tanimura A, Oritani K, Matsumura I, Kanakura Y.
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Journal Title
J Biol Chem. 285(41)
Pages: 30045-30056
Peer Reviewed
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