2010 Fiscal Year Final Research Report
Host defense against myelo -suppressive stress
| Project/Area Number |
21790923
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Keio University |
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Principal Investigator |
MIYAMOTO Kana Keio University, 医学部, 研究員 (60464997)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 血液内科学 |
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| Research Abstract |
The maintenance of haematopoietic stem cells and mobilization of haematopoietic progeniyor cells to the periphery is very important for lives. It was reported that bone marrow cavities and osteoclasts are required for maintenance of haematopoietic stem cells and mobilization of bone marrow cells to periphery, respectively. In this study, we found that bone marrow cavities and osteoclasts were both dispensable for the maintenance of haematopoietic stem cells and mobilization of bone marrow cells to p eriphery.
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[Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.2010
Author(s)
Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T.
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Journal Title
J Exp Med. 207(4)
Pages: 751-762
Peer Reviewed
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[Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner.2009
Author(s)
Miyamoto K, Ninomiya K, Sonoda K, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egarashi K, Suda T, Toyama Y, Miyamoto T.
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Journal Title
Biochem Biophys Res Commun. 383
Pages: 373-377
Peer Reviewed
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