2010 Fiscal Year Final Research Report
A role of mast cell-derived IL-31 in pruritus in atopic dermatitis
| Project/Area Number |
21791099
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Juntendo University |
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Principal Investigator |
HARA Mutsuko Juntendo University, 医学(系)研究科, 研究員 (60420832)
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| Project Period (FY) |
2009 – 2010
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| Keywords | IL-31 / 皮膚炎 / マスト細胞 |
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| Research Abstract |
In this study, we tested our hypothesis that mast cells might produce an pruritic sytokine IL-31 and play a role in prutitus in atopic dermatitis. We found that anti-microbial peptides induced IL-31 production from human mast cells and IL-31 expression was detected in mast cells in skin lesions of a mouse model of atopic dermatitis. Collectively, these results suggest that mast cell-derived IL-31 may play a role in pruritus in atopic dermatitis.
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Author(s)
Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A.
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Journal Title
J Allergy Clin Immunol. 127(4)
Pages: 1038-1045,e3
Peer Reviewed
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[Journal Article] Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells.2010
Author(s)
Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, Fukai T, Tokura T, Miyajima H, Nakao A, Ogawa H, Okumura K.
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Journal Title
Peer Reviewed
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[Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.2010
Author(s)
Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
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Journal Title
J Immunol 184(7)
Pages: 3526-3534
Peer Reviewed
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[Journal Article] FcepsilonRIalpha gene-18483A>C polymorphism affects transcriptional activity through YY1 binding.2009
Author(s)
Potaczek DP, Maeda K, Wang QH, Nakano N, Kanada S, Stepien E, Branicka A, Fukai T, Hara M, Tokura T, Ogawa H, Undas A, Okumura K, Nishiyama C.
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Journal Title
Immunogenetics. 61(9)
Pages: 649-655
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[Journal Article] Roles of PU.1 in monocyte- and mast cell-specific gene regulation : PU.1 transactivates CIITA pIV in cooperation with IFN-gamma.2009
Author(s)
Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, Kanada S, Fukuyama K, Akiba H, Tokura T, Hara M, Tsuboi R, Ogawa H, Okumura K.
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Journal Title
Int Immunol. 21(7)
Pages: 803-816
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[Journal Article] Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.2009
Author(s)
Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H.
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Journal Title
J Allergy Clin Immunol. 123(1)
Pages: 179-186
Peer Reviewed
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