Organization of genetics, the new grade for the pediatric brain tumor

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791379
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: AIHARA Yasuo Tokyo Women's Medical University, 医学部, 助教 (50287372)
• Project Period (FY): 2009 – 2010
• Keywords: 悪性脳腫瘍 / 小児 / 予後 / 悪性度分類 / 遺伝子検査 / 化学療法 / 放射線療法 / 播種

Research Abstract

We analyzed the oncocyte (27 cases in total) which we delivered from 8 onset medulloblastoma dissemination cases, glioma 5 case, ependymoma 14 case this time.The gene expression levels were different in each malignant tumor. SUFU, ERBB2, PCNA developed the disseminated meningioma as compared with a on-disseminated medulloblastoma high. The results were similar for the onset clinical manifestations.It developed high, and PDGFRa and G-CSFR resembled a gliomatous gene expression pattern in the gene expression pattern of the ependymoma in all gliomas case and showed the tendency that was different from the expression patterns of the medulloblastoma.

Research Products

• [Journal Article] High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma. (2011)
  • Author(s): Tsuruta T, Aihara Y, Kanno H, Kiyotani C, Maebayashi K, Sakauchi M, Osawa M, Fujii H, Kubo O, Okada Y.
  • Journal Title: Childs Nery Syst. 27(6) Pages: 1019-24
  • Peer Reviewed
• [Journal Article] Shared molecular targets in pediatric gliomas and ependymomas. (2011)
  • Author(s): Tsuruta T, Aihara Y, Kanno H, Funase M, Murayama T, Osawa M, Fujii H, Kubo O, Okada Y.
  • Journal Title: Pediatr Blood Cancer. doi:10.1002/pbc.23009.(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Novel method for controlling cerebrospinal fluid flow and intracranial pressure by use of a tandem shunt valve system. (2010)
  • Author(s): Aihara Y, Kawamata T, Mitsuyama T, Hori T, Okada Y.
  • Journal Title: Pediatr Neurosurg. 46(1) Pages: 12-8
  • Peer Reviewed
• [Journal Article] Clinical standard of neurosurgical disorder (15) parasellar tumor including craniopharyngioma (2010)
  • Author(s): Kawamata T, Hori T, Amano K, Aihara Y, Kubo O, Okada Y.
  • Journal Title: No Shinkei Geka.(Review. Japanese. No abstract available.) 38(2) Pages: 185-93
  • Peer Reviewed