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2010 Fiscal Year Final Research Report

The molecular mechanisms of Perlecan for vascular invasion in growth plate development

Research Project

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Project/Area Number 21791418
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionJuntendo University

Principal Investigator

ISHIJIMA Muneaki  Juntendo University, 医学部, 助教 (70365576)

Project Period (FY) 2009 – 2010
Keywords骨・軟骨代謝学
Research Abstract

Perlecan (Perl) is a heparin sulfate proteoglycan required for cartilage development. This study investigated the role of Perl for vascular invasion in growth plate development.While the vascular invasion was inhibited, VEGF expression was increased in Perl-/- growth plate. In organ culture experiment, the growth plate was expanded by the addition of FGF-FGFR inhibitor even though the absence of Perl.
These data indicate that Perl is essential for vascular invasion in growth plate development by not only modulating FGF signaling but also regulating VEGF function.

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Published: 2012-02-13   Modified: 2016-04-21  

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