2011 Fiscal Year Final Research Report
Development of neuropathic pain cure using a nerve regeneration and a neurodifferentiate factor
| Project/Area Number |
21791432
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経障害性疼痛 / Notch signal |
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| Research Abstract |
In cultures with or without EGF (epidermal growth factor) which are main growth factors with a neural stem/progenitor cells in the postnatal cerebellum, Notch 1 and Jagged 1 express into these cells. When Notch signaling activated in these cells by overexpression of Notch intracellular domein (NICD), in HERP1, and 2 and HES1, the difference was not observed in the amount of revelation of the target gene. But Activation of Notch signaling increased HES5 in these cells.
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