2010 Fiscal Year Final Research Report
Regulation of posttranslational modification of water channel aquaporin-5 in the intracellular localization and trafficking
| Project/Area Number |
21791806
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
HASEGAWA Takahiro The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (50447273)
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| Project Period (FY) |
2009 – 2010
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| Keywords | アクアポリン / 翻訳後修飾 / リン酸化 / ユビキチン化 / 細胞内膜輸送 / 唾液腺 |
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| Research Abstract |
Two types of posttranslational modification (phosphorylation and ubiquitination) of water channel aquqaporin-5 (AQP5) were found in mouse salivary gland cells. AQP5 was transiently ubiquitinated and phosphorylated through the stimulation of intracellular Ca^<2+> signaling and the cAMP signaling, respectively. Our present study reveals that the posttranslational modifications of AQP5 are involved in the saliva secretion that is regulated by sympathetic and parasympathetic nervous systems.
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