2010 Fiscal Year Final Research Report

Development of reconstruction scaffold for jaw bone made of titanium fiber web with cell induction ability

Research Project

Project/Area Number	21791945
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Yokohama City University
Principal Investigator	HIROTA Makoto Yokohama City University, 医学部, 准教授 (20347305)
Project Period (FY)	2009 – 2010
Keywords	チタンファイバー / 顎骨再建 / 生体材料 / アパタイト
Research Abstract	The aim of this study was evaluation of the bone regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method. A thin HA film was uniformly coated on a TW by the molecular precursor method, without affecting the structure of the TW. Human osteoblasts culture on TW and HA-coated TW (HA/TW) suggested that the HA coated by the molecular precursor method maintained TW architecture and accelerated osteoblast differentiation. Then, TW discs with or without thin HA coating were implanted into rat cranial cortical bone defects, suggesting a thin HA coating enhanced the cortical bone formation through maintenance of TW porosity and promotion of osteoconductivity in the TW 3-dimensional scaffold.