2013 Fiscal Year Final Research Report

The analysis of multipotential immune cells induced in oral cancer patients for development of novel immunotherapy

Research Project

Project/Area Number	21791978
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	TANAKA KAE 東京医科歯科大学, 歯学部附属病院, 助教 (20431934)
Project Period (FY)	2009-04-01 – 2013-03-31
Keywords	抗腫瘍免疫
Research Abstract	We investigated Myeloid Derived Suppressor Cells induced in tumor-bearing mice after injection with transplantable oral squamous cell carcinoma, and clarified that GM-CSF is needed to maintain these cells. But, there is difference in quantity of these cells among oral cancer patients unlike mouse model using murine oral cancer cell line producing GM-CSF, which might be depending on quantity of GM-CSF produced by human oral cancer, because there is difference in GM-CSF production individually. The analysis of the relationship between these cells and GM-CSF production is currently under investigation, concomitantly with the analysis of expression levels of B7-H3 on tumor cells in oral cancer patients.