2010 Fiscal Year Final Research Report

Development of the inhibition therapy against growth and metastasis of oral cancer targeting CXC chemokine, SDF-1

Research Project

Project/Area Number	21792003
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	The University of Tokushima
Principal Investigator	UCHIDA Daisuke The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (20335798)
Project Period (FY)	2009 – 2010
Keywords	SDF-1 / CXCR4 / 口腔癌 / 転移
Research Abstract	We have tried to inhibit both growth via CXCR7 and metastasis via CXCR4 by the inhibition of SDF-1 on the oral cancer cells. SDF-l antibody inhibited the anchorage independent growth of oral cancer cells in vitro, but did affect neither growth nor metastasis in vivo. However, a CXCR4 specific antagonist AMD3100 significantly inhibited the metastasis of oral cancer cells. These results indicated that inhibition of both CXCR4 and CXCR7 by the SDF-1 antibody is difficult, but AMD3100 may be a potent anti-metastatic therapy in cases of CXCR4-related oral cancer.