2010 Fiscal Year Final Research Report

Autograft experiment of the induced bone on the periosteum by absorptive HAp/BMP-2 to mandibular resected region.

Research Project

Project/Area Number	21792027
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	HINO Jun Health Sciences University of Hokkaido, 歯学部, 助手 (20508709)
Project Period (FY)	2009 – 2010
Keywords	吸収性セラミックス / 生体材料 / 骨膜上骨誘導 / 骨移植 / 移植・再生医療 / 超音波部分溶解析出処理
Research Abstract	The supra-periosteal implant, of the biomimctic functionally graded hydroxyapatite (fg-HAp, absorptive HAp)/BMP-2 showed high cell proliferation activity and excellent hard tissue induction. Moreover, it was suggested that the surrounding tissue become a periosteum according to the progress of the bone formation. In addition, the hydroxyapatite modified by a partial dissolution-precipitation technique using supersonic treatment might be improved the ability of hard tissue induction with BMP-2. Because a bony bridge formation between the new bone and the skull was not made, it was thought that the new bone on the periosteum could be removed easily and used for the bone graft.