2010 Fiscal Year Final Research Report

Histological analysis of a molecule involved in development of function for eating and swallowing

Research Project

Project/Area Number	21792050
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Hokkaido University
Principal Investigator	TAKASAKI Chihiro Hokkaido University, 大学院・歯学研究科, 助教 (60451449)
Project Period (FY)	2009 – 2010
Keywords	大脳皮質 / ニューロン周囲オリゴデンドロサイト / マウス / クレアチン合成酵素 / セリン合成酵素 / グルタミン合成酵素
Research Abstract	Perineuronal oligodendrocytes are unmyelinating oligodendrocytes attaching to large neurons in various neural regions. However, little is known about their cellular characteristics. In this study, we examined their cytochemical properties in the mouse cerebral cortex. Almost all perineuronal oligodendrocytes expressed glia-specific or glia-enriched metabolic enzymes. Interestingly, they attached more to glutamatergic principal neurons, when the cerebral cortex develops and maturates. These cytochemical properties suggest that perineuronal oligodendrocytes are so differentiated as to fulfill metabolic support to the associating principal cortical neurons.