2010 Fiscal Year Final Research Report
Establishment of Rat Periodontitis Model With Periodontal Pocket Formation and Elucidation of the Junctional Epithelium Destruction Mechanism
| Project/Area Number |
21792125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
YOSHINAGA Yasunori Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (60452869)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯周ポケット形成 |
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| Research Abstract |
LPS was introduced daily into the palatal gingival sulcus of first molars in LPS-sensitized (sensitized group) or non-sentized rats (non-sensitized group). There was a significantly increase in apical migration of JE, pocket formation, bone resorption, the number of RANKL-bearing cells in the sensitized group than in the non-sensitized group. We could clearly demonstrate pocket formation and bone resorption in LPS-sensitized rats on day 30.
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