Evaluation of CYP2Y6 gene polymorphisms in periodontitis associated with smoking

2010 Fiscal Year Final Research Report

• Project/Area Number: 21792136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: FUMA Daisuke Aichi Gakuin University, 歯学部, 非常勤助教 (10532971)
• Project Period (FY): 2009 – 2010
• Keywords: 遺伝子多型解析 / ニコチン代謝能 / 歯周予防学 / 喫煙関連歯周炎 / CYP2A6遺伝子

Research Abstract

Smoking is a risk factor for the initiation, extent and severity of periodontal disease. However, periodontitis of the smokers is not necessarily aggravated. Therefore, in this study, I investigated genetic polymorphisms in the CYP2Y6 gene in Japanese periodontitis patients with smoking history and periodontally healthy control subjects with smoking history. An association analysis with allelotypes showed that SNPs identified in the CYP2Y6 gene have no significant association with periodontitis associated with smoking in the Japanese population.