2010 Fiscal Year Final Research Report
Identification of novel Exophilin complexes
Project/Area Number |
21890031
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
|
Research Institution | Gunma University |
Principal Investigator |
ISIZAKI Rei Gunma University, 生体調節研究所, 助教 (90510511)
|
Project Period (FY) |
2009 – 2010
|
Keywords | インスリン分泌 / β細胞 |
Research Abstract |
The small GTPase Rab27a is expressed in pancreatic β cells and regulates insulin secretion. In this study, I found that Rab27a showed the strongest binding affinity for Granuphilin. Granuphilin is strongly expressed in pancreatic β cells and suppresses insulin secretion. Then I identified the novel Granuphilin complex. This complex inhibits function of Granuphilin and increases insulin secretion.
|
Research Products
(2 results)