Identification of novel Exophilin complexes
| Project/Area Number |
21890031
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
ISIZAKI Rei Gunma University, 生体調節研究所, 助教 (90510511)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | インスリン分泌 / β細胞 / 糖尿病 / 膵ベータ細胞 / インスリン / 分泌顆粒 |
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| Research Abstract |
The small GTPase Rab27a is expressed in pancreatic β cells and regulates insulin secretion. In this study, I found that Rab27a showed the strongest binding affinity for Granuphilin. Granuphilin is strongly expressed in pancreatic β cells and suppresses insulin secretion. Then I identified the novel Granuphilin complex. This complex inhibits function of Granuphilin and increases insulin secretion.
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Report
(3 results)
Research Products
(2 results)
