Identification of novel Exophilin complexes

Research Project

Project/Area Number	21890031
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pathological medical chemistry
Research Institution	Gunma University
Principal Investigator	ISIZAKI Rei Gunma University, 生体調節研究所, 助教 (90510511)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000) Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000) Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords	インスリン分泌 / β細胞 / 糖尿病 / 膵ベータ細胞 / インスリン / 分泌顆粒
Research Abstract	The small GTPase Rab27a is expressed in pancreatic β cells and regulates insulin secretion. In this study, I found that Rab27a showed the strongest binding affinity for Granuphilin. Granuphilin is strongly expressed in pancreatic β cells and suppresses insulin secretion. Then I identified the novel Granuphilin complex. This complex inhibits function of Granuphilin and increases insulin secretion.