2010 Fiscal Year Final Research Report
Genetic polymorphisms of antioxidant enzymes and colorectal carcinogenesis
| Project/Area Number |
21890296
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
MORITA Makiko University of Occupational and Environmental Health, Japan, 医学部, 助教 (60530491)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 大腸がん / 大腸腺腫 / 酸化ストレス / 遺伝子多型 / 分子疫学 |
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| Research Abstract |
Oxidative stress causes DNA damage and may be involved in carcinogenesis. Endogenous antioxidant enzymes are known to be defensive against oxidative stress. To clarify the influence of the oxidative stress on colorectal carcinogenesis, we investigated the relation of functional genetic polymorphisms of manganese superoxide dismutase, catalase, and glutathione peroxidase to colorectal adenomas and cancer. None of the polymorphisms under study showed a measurable association with colorectal adenoma risk. A statistically significant decrease in the risk of colorectal cancer was observed among those with the T allele of CAT-262C>T.
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