2023 Fiscal Year Final Research Report
Development of versatile system for organic reactions in water using thermoresponsive micelles and catalyst-tethered polymers
| Project/Area Number |
21K05074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 33020:Synthetic organic chemistry-related
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| Research Institution | Sophia University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 水中有機反応 |
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| Outline of Final Research Achievements |
Copolymers that form thermo-responsive micelles were synthesized by tethering a ligand moiety to an initiator of living radical polymerization. We prepared a palladium complex on the ligand at the polymer end. They served as a catalyst for carbon-carbon bond forming reactions in water as a reaction medium. The block copolymer of a poly(N-isopropylacrylamide) chain and a hydrophilic polymer chain formed micelles by heating during the reaction, to promote the reaction within the micelle core. It was found that by cooling the solution after the reaction completed, the micelles dissociated, facilitating the separation of the product by a subsequent extraction step. We also succeeded in reuse of the aqueous solution containing the catalyst.
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| Free Research Field |
有機金属化学
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| Academic Significance and Societal Importance of the Research Achievements |
有機合成プロセスを水溶媒中でおこなうことは、持続可能な産業構築のために重要である。しかしながら反応後に生成物を分離するために抽出溶媒を使用するという矛盾を克服しない限り真に環境調和型のプロセスとは言えない。温度応答性コポリマーは、ゲル等の応用研究が進む一方でそれが構成するミセルを有機合成の反応場として応用する研究は進んでいない。本研究の成果として、ポリマー末端に１つだけ触媒部位を有することでも有効に触媒として利用できること、またそれを用いてより少ない抽出溶媒で高効率に生成物を分離できることが明らかになったことは今後水系反応プロセスを開発する上で有用な情報を与える。
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