Development for automatic data analysis of large-scale glycomics

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 62010:Life, health and medical informatics-related
• Research Institution: Nagoya University (2023); Niigata University (2021-2022)
• Principal Investigator: MIURA Nobuaki 名古屋大学, 糖鎖生命コア研究所, 特任講師 (80372267)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: バイオインフォマティクス / グライコミクス / 質量分析 / MALDI

Outline of Final Research Achievements

Glycans are key molecules in biological process, and the analysis of the types and amounts of glycans in various biological states is indispensable information for understanding biological events such as diseases and aging. Glycans are analyzed by mass spectrometry. The data analysis has conventionally been done manually, and in some cases, it takes weeks to complete the analysis. In this project, data analysis has been largely automated with the support of informatics, and tools that enable analysis in "minutes" have been developed. In the course of the project, we decided to contribute to the Human Glycome Atlas Project of Nagoya University, and modified the program to be able to analyze glycans of a large population, and constructed a prototype to realize these changes.

Free Research Field

質量分析インフォマティクス

Academic Significance and Societal Importance of the Research Achievements

本研究は, これまで膨大な手間と時間を要した糖鎖解析のデータ処理を, きわめて短時間に処理することを可能とした. これによって,これまでのゲノム, トランスクリプトーム, プロテオームに加えて現実的に糖鎖, グライコームを加えた疾患機序解明のサイエンスを展開することが現実的となった. 遺伝子, そこから生じるタンパク質の機能だけでなくタンパク質に付与される糖鎖についての知見を得ることが容易になる. つまり, 生命分子全体として統合的に生命現象解明の本当のスタート地点に立てる事になる.