Generation of non-human primate disease model by loss-of-gene function

2014 Fiscal Year Final Research Report

• Project/Area Number: 22240053
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Central Institute for Experimental Animals
• Principal Investigator: sasaki erika 公益財団法人実験動物中央研究所, その他部局等, その他 (70390739)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: ノックダウン / II型糖尿病 / インスリンレセプター / マーモセット

Outline of Final Research Achievements

The common marmoset (Callithrix jacchus) is the only primate that has been used to generate transgenic animals with germline transmission of the transgene to their offspring. However, transgenic non-human primates that show loss-of-gene function are required to create various disease models. In this study, we tried generation of loss-of-gene function transgenic marmoset disease models.

Free Research Field

発生学、幹細胞学、繁殖生理学