2012 Fiscal Year Final Research Report
Elucidation of nuclear export machinery of tRNA by crystal structural analysis of exportin/tRNA complex
| Project/Area Number |
22370041
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
YAMAZAWA Ryuji 大阪大学, 蛋白質研究所, 博士研究員
KOBAYASHI Takeshi 大阪大学, 大学院・理学研究科, 博士前期課程1 年
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| Project Period (FY) |
2010 – 2012
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| Keywords | 繊結晶解析 / 核-細胞質間物質輸送 / 構造生物学 |
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| Research Abstract |
In eukaryotic cells, the nucleus, where transcription occurs, and thecytoplasm, where translation takes place, are separated by the nuclear envelope. Theregulation of nucleo-cytoplasmic transport of proteins and RNAs is essential for biologicalactivity. Here, we solve crystal structures of a nuclear export factor and export factorcomplex for non-coding RNA export from the nucleus and the crystal structures reveal RNArecognition mechanism of the nuclear export factor transporting various non cordingRNAs.
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